Evidence map›Paper›PMID 38472236›Full record

ArticleNature communications2024

Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung.

Leila R Martins, Lina Sieverling, Michelle Michelhans, Chiara Schiller, Cihan Erkut, Thomas G P Grünewald, Sergio Triana, Stefan Fröhling, Lars Velten, Hanno Glimm and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Article
  8. CCL20 secreted by KRT15Cell death & disease · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leila R MartinsDivision of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. leila.martins@nct-heidelberg.de.ORCID 0000-0002-5887-4734
Lina SieverlingNational Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.
Michelle MichelhansDivision of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Chiara SchillerDivision of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0009-0000-3771-2202
Cihan ErkutDivision of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-4378-9075
Thomas G P GrünewaldNational Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0003-0920-7377
Sergio TrianaStructural and Computational Biology, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0003-0370-7821
Stefan FröhlingNational Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0001-7907-4595
Lars VeltenCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-1233-5874
Hanno GlimmDepartment for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.ORCID 0000-0003-4104-1135
Claudia SchollDivision of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. claudia.scholl@nct-heidelberg.de.ORCID 0000-0001-6768-322X

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SFB873
6 · The paper itself

Abstract

Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung diseases. We combine mouse models allowing diphtheria toxin-mediated damage of specific epithelial cell types and parallel GFP-labeling of functionally dividing cells with single-cell transcriptomics to characterize the regeneration of the distal lung. We uncover cell types, including Krt13

Indexed as

Diphtheria ToxinLungAnimalsCell DifferentiationCell DivisionGene Expression ProfilingHumansMiceDiphtheria Toxin

Identifiers

PMID38472236
PMCPMC10933319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.