ArticleScientific reports2024
Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optical coherence tomography angiography as a tool for diagnosis and monitoring of sickle cell related eye disease: a systematic review and meta-analysis.Eye (London, England) · 2025Pooled it
- Retinal Optical Coherence Tomography-Angiography and Longitudinal Changes in Cognition and Cerebral Small Vessel Disease.Neurology · 2026Article
- AI-driven multimodal retinal imaging for early detection and risk stratification of vascular and neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Physical Activity Is Associated with Higher Retinal Microvascular Density in Uveal Melanoma and Nevus.Cancers · 2026Article
- Improved method for optical coherence tomography angiography: from reconstruction to clinical indicator quantification.Journal of biomedical optics · 2026Article
- Retinal microvascular changes in patients with ankylosing spondylitis receiving biologic therapy: a cross-sectional OCTA study.BMC ophthalmology · 2026Article
- Differentiating Alzheimer's disease and vascular dementia via combined OCT and OCT‑angiography analysis.Scientific reports · 2026Article
- Acute effects of high-intensity interval training on retinal microvascular circulation in cancer patients and healthy controls: insight from the optical coherence tomography angiography.European journal of applied physiology · 2026Article
- Vis-OCT Explorer: an open-source software for visible-light optical coherence tomography data processing.Biomedical optics express · 2026Article
- Local Versus Global Binarization Techniques After Frangi Filtering for Optical Coherence Tomography Angiography Based Retinal Vessel Density Assessment in Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2026Article
- Quantitative Comparison of Two Novel Swept-Source Optical Coherence Tomography Angiography Devices.Diagnostics (Basel, Switzerland) · 2026Article
- Optical coherence tomography angiography reveals insights into complementary vascular and neurodegenerative mechanisms in multiple sclerosis.Brain communications · 2026Article
- Longitudinal changes in anatomic biomarkers on optical coherence tomography angiography in diabetic retinopathy.Frontiers in ophthalmology · 2026Article
- Quantifying segmentation sensitivity in OCTA: Device-specific profiles across three commercial platforms.PloS one · 2026Article
- Four Months of Exercise Intervention Improved Visuomotor, Functional and Cardiorespiratory Capacity in a Patient with Metastatic Uveal Melanoma.Reports (MDPI) · 2025Article
- OCTA-ReVABiomedical optics express · 2025Article
- Relationship Between Parapapillary Microvasculature Dropout and Visual Field Defect in Glaucoma: A Cross-Sectional OCTA Analysis.Journal of clinical medicine · 2025Article
- DERMA-OCTA: A Comprehensive Dataset and Preprocessing Pipeline for Dermatological OCTA Vessel Segmentation.Scientific data · 2025Article
- Optical Coherence Tomography Angiography (OCTA) Characteristics of Acute Retinal Arterial Occlusion: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Correlating 10-2 Visual Field Loss with Structural and Angiographic Parameters in Advanced Glaucoma.Ophthalmology and therapy · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) images is important for studying, diagnosing, monitoring, and guiding the treatment of ocular and systemic diseases. However, the OCTA user community lacks universal and transparent image analysis tools that can be applied to images from a range of OCTA instruments and provide reliable and consistent microvascular metrics from diverse datasets. We present a retinal extension to the OCTA Vascular Analyser (OCTAVA) that addresses the challenges of providing robust, easy-to-use, and transparent analysis of retinal OCTA images. OCTAVA is a user-friendly, open-source toolbox that can analyse retinal OCTA images from various instruments. The toolbox delivers seven microvascular metrics for the whole image or subregions and six metrics characterising the foveal avascular zone. We validate OCTAVA using images collected by four commercial OCTA instruments demonstrating robust performance across datasets from different instruments acquired at different sites from different study cohorts. We show that OCTAVA delivers values for retinal microvascular metrics comparable to the literature and reduces their variation between studies compared to their commercial equivalents. By making OCTAVA publicly available, we aim to expand standardised research and thereby improve the reproducibility of quantitative analysis of retinal microvascular imaging. Such improvements will help to better identify more reliable and sensitive biomarkers of ocular and systemic diseases.
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