Evidence map›Paper›PMID 38472048›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2024

VEGF expression disparities in brainstem motor neurons of the SOD1

Silvia Silva-Hucha, M Estrella Fernández de Sevilla, Kirsty M Humphreys, Fiona E Benson, Jaime M Franco, David Pozo, Angel M Pastor, Sara Morcuende

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Silvia Silva-HuchaDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain; Cell and Developmental Biology, University College London, Medawar Building, Gower Street, London WC1E 6BT, UK.
M Estrella Fernández de SevillaDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain.
Kirsty M HumphreysDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK.
Fiona E BensonDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK.
Jaime M FrancoAndalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-Universidad Pablo de Olavide-Universidad de Sevilla-CSIC, 41092, Seville, Spain.
David PozoAndalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-Universidad Pablo de Olavide-Universidad de Sevilla-CSIC, 41092, Seville, Spain; Department of Medical Biochemistry, Molecular Biology and Immunology, Universidad de Sevilla Medical School, 41009 Seville, Spain.
Angel M PastorDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain. Electronic address: ampastor@us.es.
Sara MorcuendeDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain. Electronic address: smorcuende@us.es.
Universidad de Sevilla · ESLancaster University · GBCentro Andaluz de Biología Molecular y Medicina Regenerativa · ESUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness mainly due to degeneration and death of motor neurons. A peculiarity of the neurodegenerative processes is the variable susceptibility among distinct neuronal populations, exemplified by the contrasting resilience of motor neurons innervating the ocular motor system and the more vulnerable facial and hypoglossal motor neurons. The crucial role of vascular endothelial growth factor (VEGF) as a neuroprotective factor in the nervous system is well-established since a deficit of VEGF has been related to motoneuronal degeneration. In this study, we investigated the survival of ocular, facial, and hypoglossal motor neurons utilizing the murine SOD1

Indexed as

Amyotrophic Lateral SclerosisBrain StemMotor NeuronsSuperoxide Dismutase-1Vascular Endothelial Growth Factor AAnimalsDisease Models, AnimalHumansMiceMice, TransgenicSuperoxide DismutaseSod1 protein, mouseSuperoxide DismutaseSuperoxide Dismutase-1Vascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseALSBrainstem motor neuronsExtraocular systemSOD1(G93A)TDP-43VEGF

Identifiers

PMID38472048
PMCPMC11070718
OpenAlexW4392637862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.