Evidence map›Paper›PMID 38472004›Full record

SynthesisBurns : journal of the International Society for Burn Injuries2024

Neuropathic pain in burn patients - A common problem with little literature: A systematic review.

Eloise Stanton, Paul Won, Artur Manasyan, Sandeep Gurram, T Justin Gilllenwater, Haig A Yenikomshian

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Burns : journal of the International Society for Burn Injuries, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. [A compulsory course in clinical treatment of burn patients: pain and analgesia].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026
    Article
  2. Review
  3. Review
  4. Pathophysiology and management of burn injury-induced pain.Burns open : an international open access journal for burn injuries · 2025
    Article
  5. Article
  6. Burn scar pain: from mechanisms to treatments.Frontiers in physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eloise StantonKeck School of Medicine of USC, Los Angeles, CA, USA; Division of Plastic and Reconstructive Surgery, Keck Medicine of USC, Los Angeles, CA, USA.
Paul WonKeck School of Medicine of USC, Los Angeles, CA, USA; Division of Plastic and Reconstructive Surgery, Keck Medicine of USC, Los Angeles, CA, USA.
Artur ManasyanKeck School of Medicine of USC, Los Angeles, CA, USA.
Sandeep GurramKeck School of Medicine of USC, Los Angeles, CA, USA.
T Justin GilllenwaterKeck School of Medicine of USC, Los Angeles, CA, USA; Division of Plastic and Reconstructive Surgery, Keck Medicine of USC, Los Angeles, CA, USA.
Haig A YenikomshianKeck School of Medicine of USC, Los Angeles, CA, USA; Division of Plastic and Reconstructive Surgery, Keck Medicine of USC, Los Angeles, CA, USA. Electronic address: Haig.Yenikomshian@med.usc.edu.
Keck Hospital of USC · US

Funding

ACL HHS 90DPBU0007
6 · The paper itself

Abstract

backgroundThe prevalence of neuropathic pain (NP) in burn patients is reported in the literature to be as high as 80%

methodsThis systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The following databases were queried to identify relevant articles: PubMed, Cochrane, Embase, Scopus, Ovid, and Web of Science. The main outcome measures were incidence and management of NP. Secondary outcomes included risk factors for NP.

resultsIncluded articles presented findings from 11 different countries, capturing outcomes for 4366 patients. Risk factors for neuropathic pain in burn patients were identified, including older age, alcohol and substance abuse, current daily smoking, greater % total body surface area burns (TBSA), and longer hospitalizations. Pharmacologic treatments included gabapentin/pregabalin (n = 7), ascorbic acid (n = 1), and lidocaine (n = 1). Overall, the studies showed varied results regarding the efficacy of pharmacological treatments. While certain studies demonstrated gabapentanoids to be effective in reducing neuropathic symptoms, others found conflicting results. With regards to non-pharmacologic treatments, electroconvulsive therapy (n = 1), electropuncture (n = 1), nerve release/reconstruction (n = 2), and somatosensory feedback rehabilitation (n = 1) were used and demonstrated promise in reducing pain intensity and improving functionality.

conclusionsDespite NP afflicting the majority of burn patients long after their injury, this systematic review demonstrates insufficient evidence on the pathophysiology, outcomes, and risk factors in NP, as well as the efficacy of various therapies. Future prospective and randomized studies evaluating the etiology of these factors can substantially improve our treatment strategies. This can allow for the development of well-delineated and evidence-based protocols in NP management in hopes of improving quality of life and both psychological and physical function in burn patients.

Indexed as

AnalgesicsBurnsGabapentinNeuralgiaAge FactorsAnesthetics, LocalAscorbic AcidBody Surface AreaHumansLidocainePain ManagementPregabalinRisk FactorsSubstance-Related DisordersAnalgesicsAnesthetics, LocalAscorbic AcidGabapentinLidocainePregabalinBurnsItchNeuropathic pain

Identifiers

PMID38472004
PMCPMC11216128
OpenAlexW4392247384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.