Evidence map›Paper›PMID 38471834›Full record

ArticleJournal of the American Heart Association2024

Temporal Trends in the Initiation of Dialysis Among Patients With Heart Failure With or Without Diabetes: A Nationwide Study From 2002 to 2016.

Pauline Knigge, Sørine Lundberg, Jarl E Strange, Mariam E Malik, Nina Nouhravesh, Andrea K Wagner, Gunnar Gislason, Emil L Fosbøl, Nicholas Carlson, Deewa Zahir and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Pauline KniggeDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0009-0009-0634-9207
Sørine LundbergDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.
Jarl E StrangeDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0000-0002-1803-5266
Mariam E MalikDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0000-0003-0657-2176
Nina NouhraveshDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0000-0002-4891-7358
Andrea K WagnerDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.
Gunnar GislasonDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0000-0002-0548-402X
Emil L FosbølDepartment of Cardiology Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark.ORCID 0000-0002-2048-4167
Nicholas CarlsonDepartment of Cardiology Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark.ORCID 0000-0002-4374-470X
Deewa ZahirDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0000-0001-9564-6231
Charlotte AnderssonBrigham and Women's Hospital Heart and Vascular Center Boston MA USA.ORCID 0000-0001-6019-8627
Jawad H ButtDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0000-0002-7380-4144
Pardeep JhundBritish Heart Foundation Cardiovascular Research Centre University of Glasgow Glasgow United Kingdom.ORCID 0000-0003-4306-5317
Mark C PetrieBritish Heart Foundation Cardiovascular Research Centre University of Glasgow Glasgow United Kingdom.ORCID 0000-0002-6333-9496
John J V McMurrayBritish Heart Foundation Cardiovascular Research Centre University of Glasgow Glasgow United Kingdom.ORCID 0000-0002-6317-3975
Lars KøberDepartment of Cardiology Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark.ORCID 0000-0002-6635-1466
Morten SchouDepartment of Cardiology Herlev-Gentofte University Hospital Hellerup Denmark.ORCID 0000-0002-4271-2466
Gentofte Hospital · DKCopenhagen University Hospital · DKBritish Heart Foundation · GBBrigham and Women's Hospital · USGlasgow Royal Infirmary · GBUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence and distribution of acute and chronic dialysis among patients with heart failure (HF), stratified by diabetes, remain uncertain. We hypothesized that with improved survival and rising comorbidities, the demand for dialysis would increase over time. METHODS AND

resultsPatients with incident HF, aged 18 to 100 years, between 2002 and 2016, were identified using Danish nationwide registers. Primary outcomes included acute and chronic dialysis initiation, HF-related hospitalization, and all-cause mortality. These outcomes were assessed in 2002 to 2006, 2007 to 2011, and 2012 to 2016, stratified by diabetes. We calculated incidence rates (IRs) per 1000 person-years and hazard ratios (HR) using multivariable Cox regression. Of 115 533 patients with HF, 2734 patients received acute dialysis and 1193 patients received chronic dialysis. The IR was 8.0 per 1000 and 3.5 per 1000 person-years for acute and chronic dialysis, respectively. Acute dialysis rates increased significantly among patients with diabetes over time, while no significant changes occurred in those without diabetes, chronic dialysis, HF-related hospitalization, or overall mortality. Diabetes was associated with significantly higher HRs of acute and chronic dialysis, respectively, compared with patients without diabetes (HR, 2.07 [95% CI, 1.80-2.39] and 2.93 [95% CI, 2.40-3.58] in 2002 to 2006; HR, 2.45 [95% CI, 2.14-2.80] and 2.86 [95% CI, 2.32-3.52] in 2007 to 2011; and 2.69 [95% CI, 2.33-3.10] and 3.30 [95% CI, 2.69-4.06] in 2012 to 2016).

conclusionsThe IR of acute and chronic dialysis remained low compared with HF-related hospitalizations and mortality. Acute dialysis rates increased significantly over time, contrasting no significant trends in other outcomes. Diabetes exhibited over 2-fold increased rates of the outcomes. These findings emphasize the importance of continued monitoring and renal care in patients with HF, especially with diabetes, to optimize outcomes and prevent adverse events.

Indexed as

Diabetes MellitusHeart FailureComorbidityHospitalizationHumansRenal Dialysisacute dialysischronic dialysisdiabetesepidemiologyheart failurehospitalization due to heart failure

Identifiers

PMID38471834
PMCPMC11009989
OpenAlexW4392779930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.