Evidence map›Paper›PMID 38471782›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia.

Shannon N Leahy, Dominic J Vita, Kendal Broadie

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The tyrosine phosphatase STEP is a developmental suppressor of synaptogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Rasopathy-Associated Mutation Ptpn11Cellular and molecular neurobiology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shannon N LeahyDepartments of Biological Sciences, Vanderbilt University and Medical Center, Nashville, Tennessee 37235.
Dominic J VitaDepartments of Biological Sciences, Vanderbilt University and Medical Center, Nashville, Tennessee 37235.ORCID 0000-0003-2357-5707
Kendal BroadieDepartments of Biological Sciences, Vanderbilt University and Medical Center, Nashville, Tennessee 37235 kendal.broadie@vanderbilt.edu.ORCID 0000-0003-3783-6023
Vanderbilt University · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Genetic and Developmental Analyses of Fragile X SyndromeR01MH084989 · NIMH · VANDERBILT UNIVERSITY · PI BROADIE, KENDAL · 2009 to 2021
$5.5M
Training Program in Stem Cell and Regenerative Developmental BiologyT32HD007502 · NICHD · VANDERBILT UNIVERSITY · PI WRIGHT, CHRISTOPHER V · 1997 to 2022
$5.4M
In Vivo Analyses of Kinase Signaling in Learning/Memory CircuitryR01NS131557 · NINDS · VANDERBILT UNIVERSITY · PI Kendal Broadie · 2024 to 2026
$1.2M
Genetic and Developmental Analyses of Fragile X Mental Retardation ProteinR56MH084989 · NIMH · VANDERBILT UNIVERSITY · PI BROADIE, KENDAL · 2023 to 2023
$516k
NICHD NIH HHS P50 HD103537NICHD NIH HHS T32 HD007502NIMH NIH HHS R01 MH084989NIMH NIH HHS R56 MH084989NINDS NIH HHS R01 NS131557
6 · The paper itself

Abstract

Cytoplasmic protein tyrosine phosphatase nonreceptor type 11 (PTPN11) and

Indexed as

Drosophila ProteinsMAP Kinase Signaling SystemNeurogliaNeuronsPresynaptic TerminalsProtein Tyrosine Phosphatase, Non-Receptor Type 11SynapsinsSynaptic TransmissionSynaptic VesiclesAnimalsAnimals, Genetically ModifiedDrosophilaFemaleMaleMutationNeuromuscular JunctionCsw protein, DrosophilaDrosophila ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatases, Non-ReceptorSynapsinsDrosophilagliaNoonan syndrome (NS)NS with multiple lentigines (NSML)SH2 domain-containing protein tyrosine phosphatase-2 (SHP2)synapse

Identifiers

PMID38471782
PMCPMC11044113
OpenAlexW4392696373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.