Evidence map›Paper›PMID 38471757›Full record

ReviewACS nano2024

A Panorama of Extracellular Vesicle Applications: From Biomarker Detection to Therapeutics.

Sumita Das, Christopher J Lyon, Tony Hu

Abstract readReview
In one paragraph

Review in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
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  18. Metasurface-enhanced biomedical spectroscopy.Nanophotonics (Berlin, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sumita DasCenter for Cellular and Molecular Diagnostics and Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
Christopher J LyonCenter for Cellular and Molecular Diagnostics and Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.
Tony HuCenter for Cellular and Molecular Diagnostics and Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.ORCID 0000-0002-5166-4937

Funding

Direct quantitation of the circulating Mtb-peptidome for pediatric TB managementR01HD090927 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon, Charles DeBeaux Mitchell · 2017 to 2026
$4.5M
Mtb and HIV/SIV antigen peptide signatures as blood biomarkers to detect early infection to active disease in young children and NHPR01HD103511 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI LYON, CHRISTOPHER J · 2021 to 2025
$3.7M
Digital Nanoplasmonic Quantification of Tumor-derived Extracellular Vesicles in Plasma MicrosamplesU01CA252965 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y., LU, HUA · 2020 to 2024
$3.0M
A nanopore biosensor for leveling Mtb antigens in bloodR01AI144168 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon · 2022 to 2026
$3.0M
Rapid Detection of TB from Blood using Cell-Free DNA and CRISPRR01AI174964 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard S Garfein, Timothy Charles Rodwell · 2023 to 2026
$2.9M
Multiplexed detection of cell-free M. Tuberculosis DNA and its drug-resistant variants in bloodR01AI175618 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Zhen Huang, Jeffrey Tornheim · 2023 to 2026
$2.9M
Diagnostic Innovations for Pediatric Tuberculosis in BoliviaR01AI173021 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI ROBERT H GILMAN, Bo Ning · 2023 to 2026
$2.8M
CRISPR detection of circulating cell-free Mycobacterium avium complex (MAC) DNA for rapid diagnosis and monitoring of MAC pulmonary diseaseR01AI177986 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bo Ning, Kevin Loring Winthrop · 2024 to 2026
$2.3M
CRISPR-TB for pediatric TB diagnosis and treatment responseR01AI179714 · NIAID · UNIVERSITY OF WASHINGTON · PI Sylvia LaCourse · 2024 to 2026
$2.2M
Quantification of brain-derived extracellular vesicle microRNAs in blood by a liposome-mediated CRISPR assay for traumatic brain injury detectionR21NS130542 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y. · 2022 to 2022
$437k
NCI NIH HHS U01 CA252965NIAID NIH HHS R01 AI144168NIAID NIH HHS R01 AI173021NIAID NIH HHS R01 AI174964NIAID NIH HHS R01 AI175618NIAID NIH HHS R01 AI177986NIAID NIH HHS R01 AI179714NICHD NIH HHS R01 HD090927NICHD NIH HHS R01 HD103511NINDS NIH HHS R21 NS130542
6 · The paper itself

Abstract

Extracellular vesicles (EVs) secreted by all cell types are involved in the cell-to-cell transfer of regulatory factors that influence cell and tissue phenotypes in normal and diseased tissues. EVs are thus a rich source of biomarker targets for assays that analyze blood and urinary EVs for disease diagnosis. Sensitive biomarker detection in EVs derived from specific cell populations is a key major hurdle when analyzing complex biological samples, but innovative approaches surveyed in this Perspective can streamline EV isolation and enhance the sensitivity of EV detection procedures required for clinical application of EV-based diagnostics and therapeutics, including nanotechnology and microfluidics, to achieve EV characterizations. Finally, this Perspective also outlines opportunities and challenges remaining for clinical translation of EV-based assays.

Indexed as

Extracellular VesiclesBiological TransportBiomarkersNanotechnologyPhenotypeBiomarkersanalysisdetectiondiagnosticdisease biomarkersextracellular vesiclesnanocarrierstargeted deliverytechniquestherapeutics

Identifiers

PMID38471757
PMCPMC11008359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.