ArticleJournal of the American College of Cardiology2024
Transcatheter Myotomy to Reduce Left Ventricular Outflow Obstruction.
Article in Journal of the American College of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Mitral Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.JACC. Cardiovascular interventions · 2026Guideline
- The Expanding Therapeutic Armamentarium for Mitral Regurgitation: Surgical and Transcatheter Interventions.Biomedicines · 2026Review
- Early Experience With the Septal Scoring Along the Midline Endocardium (SESAME) Technique in the Asia-Pacific Region.JACC. Case reports · 2026Article
- Adapting Interventional Echocardiography to New Techniques: Echocardiographic Guidance for Transcatheter Myotomy Using Septal Scoring Along the Midline Endocardium.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2026Article
- Delayed Presentation of Suicide LV: Post-AVR LVOT Obstruction Cured by Alcohol Septal Ablation.Acta Cardiologica Sinica · 2026Article
- Expanding the Toolbox for Mitral Valve-in-Valve Therapy: Innovation Demands Evidence.JACC. Case reports · 2026Article
- Current Evidence, Emerging Evidence, and Decision-Making: An Algorithm for Leaflet Modification Procedures.JACC. Cardiovascular interventions · 2026Review
- Mitral Transcatheter Edge-to-Edge Repair in Non-Surgical Candidates with Hypertrophic Obstructive Cardiomyopathy: Clip It, or Ablate It?Journal of cardiovascular development and disease · 2026Review
- Transcatheter mitral valve replacement.Herz · 2026Article
- 2026 Expert Consensus Recommendations on Hypertrophic Cardiomyopathy: A Report of the Task Force of the Taiwan Society of Cardiology.Acta Cardiologica Sinica · 2026Article
- Transcaval SESAME, LAMPOON, and Valve-in-MAC: First Experience With SESAME Outside the United States.JACC. Case reports · 2026Article
- Transcatheter Valve Replacement for Mitral Stenosis: A State of the Art Review.Journal of clinical medicine · 2026Review
- Review
- Transesophageal Echocardiography in Transcatheter Mitral Valve Replacement.Journal of clinical medicine · 2025Review
- Alcohol Septal Ablation Before TAVR in Patients With Concomitant LVOT Obstruction and Severe Aortic Stenosis: A Single-Center Study.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- The Emerging Role of Lithotripsy in Structural Heart Interventions.Current cardiology reports · 2025Review
- SESAME to Treat Subaortic Membrane: First-in-Human Experience.JACC. Cardiovascular interventions · 2025Article
- Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms (VINTAGE): Initial Human Experience.JACC. Clinical electrophysiology · 2025Article
- SESAME technique: septal scoring along the midline endocardium.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Concurrent Use of Tafamidis and Mavacamten for Transthyretin Cardiac Amyloidosis With Severe Outflow Tract Obstruction.JACC. Case reports · 2025Article
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular outflow tract (LVOT) obstruction is a source of morbidity in hypertrophic cardiomyopathy (HCM) and a life-threatening complication of transcatheter mitral valve replacement (TMVR) and transcatheter aortic valve replacement (TAVR). Available surgical and transcatheter approaches are limited by high surgical risk, unsuitable septal perforators, and heart block requiring permanent pacemakers.
objectivesThe authors report the initial experience of a novel transcatheter electrosurgical procedure developed to mimic surgical myotomy.
methodsWe used septal scoring along midline endocardium (SESAME) to treat patients, on a compassionate basis, with symptomatic LVOT obstruction or to create space to facilitate TMVR or TAVR.
resultsIn this single-center retrospective study between 2021 and 2023, 76 patients underwent SESAME. In total, 11 (14%) had classic HCM, and the remainder underwent SESAME to facilitate TMVR or TAVR. All had technically successful SESAME myocardial laceration. Measures to predict post-TMVR LVOT significantly improved (neo-LVOT 42 mm
conclusionsWith further experience, SESAME may benefit patients requiring septal reduction therapy for obstructive hypertrophic cardiomyopathy as well as those with LVOT obstruction after heart valve replacement, and/or can help facilitate transcatheter valve implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.