Evidence map›Paper›PMID 38471459›Full record

ArticleNeonatology2024

Temporal Trends in Severe Brain Injury and Associated Outcomes in Very Preterm Infants.

Abdul Razak, Emily Johnston, Alice Stewart, Marissa A T Clark, Penelope Stevens, Margaret Charlton, Flora Wong, C McDonald, Rod W Hunt, Suzanne Miller and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neonatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Abdul RazakDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Emily JohnstonMonash Newborn, Monash Children's Hospital, Melbourne, Victoria, Australia.
Alice StewartDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Marissa A T ClarkMonash Newborn, Monash Children's Hospital, Melbourne, Victoria, Australia.
Penelope StevensMonash Newborn, Monash Children's Hospital, Melbourne, Victoria, Australia.
Margaret CharltonMonash Newborn, Monash Children's Hospital, Melbourne, Victoria, Australia.
Flora WongDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
C McDonaldThe Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
Rod W HuntDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Suzanne MillerThe Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
Atul MalhotraDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Monash Children’s Hospital · AUHudson Institute of Medical Research · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSevere brain injury (SBI), including severe intraventricular haemorrhage (sIVH) and cystic periventricular leukomalacia, poses significant challenges for preterm infants, yet recent data and trends are limited.

methodsAnalyses were conducted using the Australian and New Zealand Neonatal Network data on preterm infants born <32 weeks' gestation admitted at Monash Children's Hospital, Australia, from January 2014 to April 2021. The occurrence and trends of SBI and sIVH among preterm infants, along with the rates and trends of death and neurodevelopmental impairment (NDI) in SBI infants were assessed.

resultsOf 1,609 preterm infants, 6.7% had SBI, and 5.6% exhibited sIVH. A total of 37.6% of infants with SBI did not survive to discharge, with 92% of these deaths occurring following redirection of clinical care. Cerebral palsy was diagnosed in 65.2% of SBI survivors, while 86.4% of SBI survivors experienced NDI. No statistically significant differences were observed in the temporal trends of SBI (adjusted OR [95% CI] 1.08 [0.97-1.20]; p = 0.13) or sIVH (adjusted OR [95% CI] 1.09 [0.97-1.21]; p = 0.11). Similarly, there was no statistically significant difference noted in the temporal trend of the composite outcome, which included death or NDI among infants with SBI (adjusted OR [95% CI] 0.90 [0.53-1.53]; p = 0.71).

conclusionNeither the rates of SBI nor its associated composite outcome of death or NDI improved over time. A notable proportion of preterm infants with SBI faced redirection of care and subsequent mortality, while most survivors exhibited adverse neurodevelopmental challenges. The development of better therapeutic interventions is imperative to improve outcomes for these vulnerable infants.

Indexed as

Brain InjuriesInfant, Extremely PrematureAustraliaCerebral Intraventricular HemorrhageCerebral PalsyFemaleGestational AgeHumansInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLeukomalacia, PeriventricularMaleNeurodevelopmental DisordersNew ZealandBrain injuryDeathIntraventricular haemorrhageMortalityPeriventricular leukomalaciaPretermRedirection of careTrends

Identifiers

PMID38471459
PMCPMC11318581
OpenAlexW4392683120

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.