ArticleThe American journal of tropical medicine and hygiene2024
Low Rate of Asymptomatic Dengue Infection Detected in Coastal Kenya Using Pooled Polymerase Chain Reaction Testing.
Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Temporal Variation and Human Host Predominance inPathogens (Basel, Switzerland) · 2025Article
- Non-household environments make a major contribution to dengue transmission: implications for vector control.Royal Society open science · 2025Article
- Comparison of unmanned aerial vehicle imaging to ground truth walkthroughs for identifying and classifying trash sites serving as potential Aedes aegypti breeding grounds.Parasites & vectors · 2025Article
- Geographic origin and evolution of dengue virus serotypes 1 and 3 circulating in Africa.Virus evolution · 2025Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Asymptomatic dengue virus (DENV) infections have important public health implications but are challenging to identify. We performed a cross-sectional study of reverse transcription quantitative polymerase chain reaction on pooled sera of asymptomatic individuals from the south coast of Kenya at two time periods to identify cases of asymptomatic viremia. Among 2,460 samples tested in pools of 9 or 10, we found only one positive case (0.04% incidence). Although pooling of samples has the potential to be a cost-effective and time-efficient method for asymptomatic DENV detection, mass cross-sectional pooled testing may not provide accurate data on rates of asymptomatic infection, likely owing to a decrease in the sensitivity with pooling of samples, a short period of viremia, or testing in the absence of an outbreak.
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