ArticleAesthetic surgery journal2024
Long-term Insights: Histopathological Assessment of Polyurethane Implant Capsules Over 24 Years.
Article in Aesthetic surgery journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Breast Capsule Thickness and Clinical Capsular Contracture: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response.Nature communications · 2026Article
- Augmentation Mastopexy With Polyurethane-Coated Implants in the Prepectoral Plane: A 24-Month Follow-Up Study.Aesthetic surgery journal. Open forum · 2026Article
- Prepectoral Breast Reconstruction: Early and Long-Term Complications and Outcomes of Total Coverage Acellular Dermal Matrix and Implants Vs Polyurethane-Coated Implants Without Use of Acellular Dermal Matrix.Aesthetic surgery journal · 2025Article
- Poly-4-hydroxybutyrate mesh (GalaFlex®) in aesthetic breast surgery: A comprehensive systematic review.JPRAS open · 2025Review
- Postmarket Study of Silimed's Silicone Gel Polyurethane Foam-covered Breast Implants: Interim Results (2018-2024).Plastic and reconstructive surgery. Global open · 2025Article
- Post-Mastectomy Direct-to-Implant Pre-Pectoral Breast Reconstruction With Polyurethane-Coated Implants: A Systematic Review of Efficacy and Safety.Aesthetic surgery journal. Open forum · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolyurethane (PU)-coated breast implants are known for their strong integration into breast tissue and the formation of capsules around them. However, capsular contracture can pose both aesthetic and clinical challenges.
objectivesThe objectives of this study were to analyze the biological and morphological characteristics of the capsular tissue surrounding PU-coated implants, irrespective of their contracture status, and to assess their potential suitability as a flap in revisional breast surgery for capsular contracture.
methodsA total of 23 tissue samples were harvested from the capsules surrounding PU-coated breast implants in 12 female patients during replacement or revisional surgery. We evaluated collagen abundance, cellular and vascular density, inflammation, collagen band types and alignment, synovial metaplasia, capsule thickness, and the expression of inflammatory biomarkers and myofibroblasts with immunohistochemical techniques. Scanning electron microscopy was employed to assess implant surface characteristics over time.
resultsWe found a significant association of capsule contraction with longer implantation durations and greater implant surface roughness (P = .018 and P = .033, respectively). Synovial metaplasia was significantly more frequent in noncontracted capsules (P = .0049). Both capsule types consisted of paucicellular, type I collagen-rich compact fibrous tissue with low vascularization. There was a marked reduction in inflammatory cells within the foreign body granuloma. The expression of inflammatory biomarkers in the capsular tissue was negligible.
conclusionsGiven the reduced levels of inflammatory and vascular components within the dense, fibrous capsular tissue, we consider them to be viable alternatives for capsular flaps in revisional surgery. This strategy has the potential to mimic the reconstruction achieved with acellular dermal matrix. LEVEL OF EVIDENCE: 4:
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