Evidence map›Paper›PMID 38470857›Full record

ArticleThe Journal of infectious diseases2024

Patient and Immunological Factors Associated With Delayed Clearance of Mucosal Severe Acute Respiratory Syndrome Coronavirus 2 RNA and Symptom Persistence.

Mars Stone, Bryan R Spencer, Donald E Warden, Rebecca V Fink, Paula Saa, Jennifer Leddy, Jackie Mulach-Vannoy, Rebecca Townsend, David Krysztof, Alexandria N Hughes and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Mars StoneVitalant Research Institute, San Francisco, California.ORCID 0000-0001-5619-2767
Bryan R SpencerScientific Affairs, American Red Cross.
Donald E WardenWestat, Rockville, Maryland.
Rebecca V FinkWestat, Rockville, Maryland.
Paula SaaScientific Affairs, American Red Cross.
Jennifer LeddyVitalant Research Institute, San Francisco, California.
Jackie Mulach-VannoyVitalant Research Institute, San Francisco, California.
Rebecca TownsendScientific Affairs, American Red Cross.
David KrysztofScientific Affairs, American Red Cross.
Alexandria N HughesWestat, Rockville, Maryland.
Clara Di GermanioVitalant Research Institute, San Francisco, California.
Debra A KesslerNew York Blood Center Enterprises, New York, New York.
Steven KleinmanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Michael P BuschVitalant Research Institute, San Francisco, California.
Philip J NorrisVitalant Research Institute, San Francisco, California.ORCID 0000-0003-0526-2088
American Red Cross · USUniversity of California, San Francisco · USWestat (United States) · USPacific Research Institute · USNew York Blood Center · USUniversity of British Columbia · CA

Funding

(REDS-IV-P) RECIPIENT EPIDEMIOLOGY AND DONOR EVALUATION STUDY IV-DATA75N92019D00032 · NHLBI · WESTAT, INC. · PI CHAPMAN, KATHY · 2019 to 2025
$19.6M
REDS-IV-P - CENTER FOR TRANSFUSION LABORATORY STUDIES (CTLS) - SARS-CoV-2/COVID-19 STUDIES75N92019D00033 · NHLBI · VITALANT · PI NORRIS, PHILIP J. · 2019 to 2024
$15.6M
National Institute of Allergy and Infectious DiseasesNHLBI NIH HHS 75N92019D00032NHLBI NIH HHS 75N92019D00033NHLBI NIH HHS HHSN 75N92019D00032NIH HHS
6 · The paper itself

Abstract

Serial blood and mucosal samples were characterized for 102 participants enrolled a median of 7.0 days after coronavirus disease 2019 diagnosis. Mucosal RNA was detectable for a median of 31.5 (95% confidence interval [CI], 20.5-63.5) days, with persistence ≥1 month associated with obesity (body mass index [BMI] ≥30 kg/m2; odds ratio [OR], 3.9 [95% CI, 1.2-13.8]) but not age, sex, or chronic conditions. Fifteen participants had likely reinfection; lower serum anti-spike IgG levels were associated with reinfection risk. Nearly half of participants (47%) reported symptoms lasting ≥2-3 months; persistence ≥3 months was associated with BMI ≥30 kg/m2 (OR, 4.2 [95% CI, 1.1-12.8]) and peak anti-spike and anti-nucleocapsid antibody levels.

Indexed as

Antibodies, ViralCOVID-19RNA, ViralSARS-CoV-2AdultAgedFemaleHumansImmunoglobulin GMaleMiddle AgedReinfectionAntibodies, ViralImmunoglobulin GRNA, ViralantibodiesCOVID-19long COVIDobesitySARS-CoV-2

Identifiers

PMID38470857
PMCPMC11326823
OpenAlexW4392688011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.