Evidence map›Paper›PMID 38470269›Full record

ArticlemBio2024

Joana Gaifem, Ana Mendes-Frias, Mathis Wolter, Alex Steimle, Maria Jose Garzón, Carles Ubeda, Clarisse Nobre, Abigail González, Salomé S Pinho, Cristina Cunha and 5 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Virulence · 2026
    Article
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  5. Article
  6. Article
  7. Article
  8. Unveiling the Molecular Repertoire ofJournal of microbiology and biotechnology · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
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  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Joana GaifemLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0001-7306-7378
Ana Mendes-FriasLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Mathis WolterDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Alex SteimleDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Maria Jose GarzónFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.
Carles UbedaFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.
Clarisse NobreCentre of Biological Engineering (CEB), University of Minho, Campus de Gualtar, Braga, Portugal.
Abigail GonzálezCentre of Biological Engineering (CEB), University of Minho, Campus de Gualtar, Braga, Portugal.
Salomé S Pinhoi3S - Institute for Research and Innovation in Health, University of Porto, Porto, Portugal.
Cristina CunhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Agostinho CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0001-8935-8030
António Gil CastroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Mahesh S DesaiDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-9223-2209
Fernando RodriguesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0001-8436-9398
Ricardo SilvestreLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0002-9270-2717
University of Minho · PTFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTLuxembourg Institute of Health · LUUniversidade do Porto · PTUniversity of Luxembourg · LUUniversity of Southern Denmark · DK

Funding

European Crohn's and Colitis Organisation (ECCO) ECCO Grant 2023European Crohn's and Colitis Organisation (ECCO) ECCO Pioneer Award 2022European Society of Clinical Microbiology and Infectious Diseases (ESCMID) ESCMID Research Grant 2022Fonds National de la Recherche Luxembourg (FNR) 22/17426243Fonds National de la Recherche Luxembourg (FNR) C15/BM/10318186Fonds National de la Recherche Luxembourg (FNR) C18/BM/12585940GVA | Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana (CIUCSD) PCIN-2015-094MEC | Fundação para a Ciência e a Tecnologia (FCT) 10.54499/2020.00185.CEECIND/CP1600/CT0004MEC | Fundação para a Ciência e a Tecnologia (FCT) 10.54499/2021.01234.CEECIND/CP1664/CT0019MEC | Fundação para a Ciência e a Tecnologia (FCT) 10.54499/CEECIND/04058/2018/CP1581/CT0015MEC | Fundação para a Ciência e a Tecnologia (FCT) 2021.06268.BDMEC | Fundação para a Ciência e a Tecnologia (FCT) 2021.07836.BDMEC | Fundação para a Ciência e a Tecnologia (FCT) LA/P/0029/2020MEC | Fundação para a Ciência e a Tecnologia (FCT) UIDB/04469/2020MEC | Fundação para a Ciência e a Tecnologia (FCT) UIDB/50026/2020MEC | Fundação para a Ciência e a Tecnologia (FCT) UIDP/50026/2020Ministerio de Ciencia e Innovación (MCIN) PID2020-120292RB-I00
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract. The etiology of IBD remains elusive, but the disease is suggested to arise from the interaction of environmental and genetic factors that trigger inadequate immune responses and inflammation in the intestine. The gut microbiome majorly contributes to disease as an environmental variable, and although some causative bacteria are identified, little is known about which specific members of the microbiome aid in the intestinal epithelial barrier function to protect from disease. While chemically inducing colitis in mice from two distinct animal facilities, we serendipitously found that mice in one facility showed remarkable resistance to disease development, which was associated with increased markers of epithelial barrier integrity. Importantly, we show that IMPORTANCE: The contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. Nevertheless, the etiology of inflammatory bowel disease, which is known to be influenced by genetics, immune response, and environmental cues, remains unclear. Unlocking novel players involved in the dictation of a protective gut, namely, in the microbiota component, is therefore crucial to develop novel strategies to tackle IBD. Herein, we revealed a synergistic interaction between two commensal bacterial strains,

Indexed as

BacteroidetesColitisInflammatory Bowel DiseasesAkkermansiaAnimalsImmunity, InnateInflammationLymphocytesMiceVerrucomicrobiaAkkermansia muciniphilacolitisgut immunityILCmicrobiomeParabacteroides distasonis

Identifiers

PMID38470269
PMCPMC11210198
OpenAlexW4392895728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.