Evidence map›Paper›PMID 38470113›Full record

ArticleInfection and immunity2024

Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA).

David J Vance, Saiful Basir, Carol Lyn Piazza, Graham G Willsey, H M Emranul Haque, Jacque M Tremblay, Michael J Rudolph, Beatrice Muriuki, Lisa Cavacini, David D Weis and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. OspA antibodies inhibit theInfection and immunity · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

David J VanceDivision of Infectious Diseases, New York State Department of Health, Wadsworth Center, Albany, New York, USA.ORCID 0000-0002-9913-7722
Saiful BasirDepartment of Biomedical Sciences, University at Albany, Albany, New York, USA.
Carol Lyn PiazzaDivision of Infectious Diseases, New York State Department of Health, Wadsworth Center, Albany, New York, USA.
Graham G WillseyDivision of Infectious Diseases, New York State Department of Health, Wadsworth Center, Albany, New York, USA.
H M Emranul HaqueDepartment of Chemistry, The University of Kansas, Lawrence, Kansas, USA.
Jacque M TremblayDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Michael J RudolphNew York Structural Biology Center, New York, New York, USA.
Beatrice MuriukiDepartment of Medicine, University of Massachusetts Chan School of Medicine, Worcester, Massachusetts, USA.
Lisa CavaciniDepartment of Medicine, University of Massachusetts Chan School of Medicine, Worcester, Massachusetts, USA.
David D WeisDepartment of Chemistry, The University of Kansas, Lawrence, Kansas, USA.
Charles B ShoemakerDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Nicholas J MantisDivision of Infectious Diseases, New York State Department of Health, Wadsworth Center, Albany, New York, USA.ORCID 0000-0002-5083-8640
New York State Department of Health · USTufts University · USUniversity of Kansas · USUniversity of Massachusetts Chan Medical School · USNew York Structural Biology Center · USUniversity at Albany, State University of New York · US

Funding

Tickborne Disease: B cell epitope discovery and mechanisms of antibody Protection75N93019C00040 · NIAID · NYSDOH/HEALTH RESEARCH, INC. · PI MANTIS, NICHOLAS J. · 2019 to 2023
$10.3M
NIAID NIH HHS 75N93019C00040
6 · The paper itself

Abstract

Camelid-derived, single-domain antibodies (V

Indexed as

LipoproteinsLyme DiseaseSingle-Domain AntibodiesAnimalsAntibodies, BacterialAntibodies, MonoclonalAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesDogsEpitopesHumansLyme Disease VaccinesAntibodies, BacterialAntibodies, MonoclonalAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesEpitopesLipoproteinsLyme Disease VaccinesOspA proteinSingle-Domain AntibodiesBorrelia burgdorferiLyme diseasemonoclonal antibodiesvaccines

Identifiers

PMID38470113
PMCPMC11003225
OpenAlexW4392895835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.