Evidence map›Paper›PMID 38470096›Full record

ArticleCNS neuroscience & therapeutics2024

Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma.

Mengwan Wu, Ying Shi, Yuyang Liu, Hongxiang Huang, Jiajia Che, Jing Shi, Chuan Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mengwan WuDepartment of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Ying ShiDepartment of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yuyang LiuDepartment of Neurosurgery, 920th Hospital of Joint Logistics Support Force, Kunming, China.
Hongxiang HuangDepartment of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang, China.
Jiajia CheDepartment of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Jing ShiDepartment of Neurosurgery, 920th Hospital of Joint Logistics Support Force, Kunming, China.
Chuan XuDepartment of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.ORCID 0000-0002-5320-2277
University of Electronic Science and Technology of China · CNNanchang University · CN

Funding

Funds from Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital 2022X045Medico-Engineering Cooperation Funds from University of Electronic Science and Technology of China ZYGX2021YGCX004Medico-Engineering Cooperation Funds from University of Electronic Science and Technology of China ZYGX2021YGCX018National Key Research and Development Program of China 2023YFC3402100The National Natural Science Foundation of China 82203539The National Natural Science Foundation of China 92259102
6 · The paper itself

Abstract

aimsGlioblastoma is the most frequent and aggressive primary brain tumor, characterized by rapid disease course and poor treatment responsiveness. The abundance of immunosuppressive macrophages in glioblastoma challenges the efficacy of novel immunotherapy.

methodsBulk RNA-seq and single-cell RNA-seq of glioma patients from public databases were comprehensively analyzed to illustrate macrophage infiltration patterns and molecular characteristics of podoplanin (PDPN). Multiplexed fluorescence immunohistochemistry staining of PDPN, GFAP, CD68, and CD163 were performed in glioma tissue microarray. The impact of PDPN on macrophage immunosuppressive polarization was investigated using a co-culture system. Bone marrow-derived macrophages (BMDMs) and OT-II T cells isolated from BALB/c and OT-II mice respectively were co-cultured to determine T-cell adherence. Pathway alterations were probed through RNA sequencing and western blot analyses.

resultsOur findings demonstrated that PDPN is notably correlated with the expression of CD68 and CD163 in glioma tissues. Additionally, macrophages phagocytosing PDPN-containing EVs (EVs

conclusionsThis investigation underscores that EVs

Indexed as

ExosomesGlioblastomaGliomaAnimalsHumansImmune ToleranceMicePodoplaninTranscription FactorsTumor-Associated MacrophagesPDPN protein, humanPdpn protein, mousePodoplaninTranscription FactorsexosomeGBMgliomaimmunosuppressive TMEmacrophagePDPN

Identifiers

PMID38470096
PMCPMC10929222
OpenAlexW4392709802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.