ArticleMovement disorders clinical practice2024
Impact of Acute Dopamine Replacement on Cognitive Function in Parkinson's Disease.
Article in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Apathy in Parkinson's Disease: Distinguishing Overlapping Symptoms Via Network Analysis.Movement disorders clinical practice · 2026Article
- Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Investigating Dopamine Replacement-Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Attention/Working Memory and Executive Function in Parkinson's Disease: Review, Critique, and Recommendations.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- Cortical α4β2-nicotinic acetylcholine receptors and cognitive decline in Parkinson's disease.Journal of Parkinson's disease · 2025Article
- Does exercise demonstrate a dose-dependent benefit with cognition in Parkinson's disease?Parkinsonism & related disorders · 2025Article
- Montreal cognitive assessment as a cognitive outcome measure in progressive supranuclear palsy.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPD causes striatal dopaminergic denervation in a posterior/dorsal to anterior/ventral gradient, leaving motor and associative cortico-striato-pallido-thalamic loops differentially susceptible to hyperdopaminergic effects with treatment. As the choice and titration of symptomatic PD medications are guided primarily by motor symptoms, it is important to understand their cognitive implications.
objectiveTo investigate the effects of acute dopaminergic medication administration on executive function in Parkinson's disease (PD).
methodsParticipants with idiopathic PD were administered the oral Symbol Digit Modalities Test (SDMT; n = 181) and the Stroop test (n = 172) in the off-medication and "best on" medication states. ANCOVA was used to test for differences between off-medication and on-medication scores corrected for age and years of education.
resultsAfter administration of symptomatic medications, scores worsened on the SDMT (F = 11.70, P < 0.001, d = -0.13), improved on the Stroop color (F = 26.89, P < 0.001, d = 0.184), word (F = 6.25, P = 0.013, d = 0.09), and color-word (F = 13.22, P < 0.001, d = 0.16) test components, and the Stroop difference and ratio-based interference scores did not significantly change. Longer disease duration correlated with lower scores on the SDMT, Stroop color, word, and color-word scores; however, longer disease duration and higher levodopa-equivalents correlated with higher Stroop difference-based interference scores.
conclusionsSymptomatic medication differentially affects performance on two cognitive tests in PD. After acute treatment, core Stroop measures improved, Stroop interference was unchanged, and SDMT performance worsened, likely reflecting complex changes in processing speed and executive function related to acute treatment. When considering motor symptom therapies in PD, an individual's cognitive demands and expectations, especially regarding executive function, should be considered.
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