Evidence map›Paper›PMID 38469567›Full record

ArticleJournal of asthma and allergy2024

A Case of Type I Food Allergy Induced by Monosodium Glutamate.

Reeko Osada, Chiyako Oshikata, Yuichi Kurihara, Kosuke Terada, Yuka Kodama, Yuga Yamashita, Ryo Nakadegawa, Hinako Masumitsu, Yuto Motobayashi, Hirokazu Takayasu and 7 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of asthma and allergy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Reeko OsadaDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Chiyako OshikataDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Yuichi KuriharaDepartment of Dermatology, Hiratsuka City Hospital, Hiratsuka, Japan.ORCID 0000-0001-9089-6477
Kosuke TeradaDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Yuka KodamaDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Yuga YamashitaDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Ryo NakadegawaDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Hinako MasumitsuDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Yuto MotobayashiDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Hirokazu TakayasuDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Nami MasumotoDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Saki ManabeDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Yingyao ZhuDepartment of Dermatology, Hiratsuka City Hospital, Hiratsuka, Japan.ORCID 0000-0001-6100-1515
Ryo TanakaDepartment of Dermatology, Hiratsuka City Hospital, Hiratsuka, Japan.
Takeshi KanekoDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Aya SasakiDepartment of Clinical Laboratory, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.ORCID 0000-0001-7607-4987
Naomi TsurikisawaDepartment of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.ORCID 0000-0001-9722-4569
National Hospital Organization · JPHiratsuka City Hospital · JPTokyo Dental College Ichikawa General Hospital · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monosodium glutamate (MSG), a salt form of a non-essential amino acid, is widely used as a food additive, particularly in Asian cuisines, due to its unique flavor-enhancing qualities. Type I allergic reactions to MSG have not previously been reported. Our patient, a 21-year-old woman, was 14 years old when she first noticed swelling of her tongue (but no oral itching, diarrhea, or abdominal pain) after eating various snack foods. Current skin prick testing elicited a weak positive reaction to MSG. We then performed an oral challenge test during which our patient ingested potato snacks. Subsequent histology showed telangiectasia of the buccal mucosa, interstitial edema in the subepithelial submucosa, and mast cell infiltration. Oral mucosal challenge tests using sodium glutamate confirmed oral swelling in this patient. This report is the first to confirm a case of type 1 allergy to MSG by combining pathology findings with the results of challenge testing.

Indexed as

food additivefood allergymast cellmonosodium glutamate

Identifiers

PMID38469567
PMCPMC10926854
OpenAlexW4392554766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.