Evidence map›Paper›PMID 38469553›Full record

ReviewAlzheimer's & dementia (New York, N. Y.)

New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.

Maria A Telpoukhovskaia, Thomas J Murdy, Olivia J Marola, Kevin Charland, Michael MacLean, Tain Luquez, Alexandra M Lish, Sarah Neuner, Amy Dunn, Kristen D Onos and 13 more

Open access · goldAbstract readReview
In one paragraph

Review in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 2 countries.

Maria A TelpoukhovskaiaThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.ORCID https://orcid.org/0000-0002-5237-4042
Thomas J MurdyThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Olivia J MarolaThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Kevin CharlandThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Michael MacLeanThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Tain LuquezCenter for Translational and Computational Neuroimmunology Department of Neurology Columbia University Irving Medical Center New York New York USA.
Alexandra M LishAnn Romney Center for Neurologic Diseases Department of Neurology Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA.
Sarah NeunerDepartment of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA.
Amy DunnThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Kristen D OnosThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Jesse WileySage Bionetworks Seattle Washington USA.
Derek ArcherVanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Nashville Tennessee USA.
Matthew J HuentelmanNeurogenomics Division Translational Genomics Research Institute (TGen) Phoenix Arizona USA.
Matthias ArnoldInstitute of Computational Biology Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg Germany.
Vilas MenonCenter for Translational and Computational Neuroimmunology Department of Neurology Columbia University Irving Medical Center New York New York USA.
Alison GoateDepartment of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA.
Linda J Van EldikSanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA.
Paul R TerritoDepartment of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA.
Gareth R HowellThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Gregory W CarterThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Kristen M S O'ConnellThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
Catherine C KaczorowskiThe Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.
2022 JAX CADR Workshop
Jackson Laboratory · USTufts University · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USBrigham and Women's Hospital · USDuke University · USIndiana University School of MedicineSage Bionetworks · USTranslational Genomics Research Institute · USUniversity of Kentucky · USUniversity of Michigan · USVanderbilt University · US

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Bruce T Lamb · 2016 to 2026
$95.6M
TREAT AD Structural Biology CoreU54AG065187 · NIA · EMORY UNIVERSITY · PI Gregory W Carter, ALLAN I LEVEY · 2019 to 2026
$69.7M
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
Veterinary and Colony Management CoreU19AG074866 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gregory W Carter · 2022 to 2026
$44.9M
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Johns Hopkins University Trial Innovation CenterU24TR004440 · NCATS · JOHNS HOPKINS UNIVERSITY · PI DANIEL F HANLEY · 2023 to 2026
$19.6M
RETINAL DISEASE: MOLECULAR BASIS AND PATHOPHYSIOLOGYR01EY011996 · NEI · JACKSON LABORATORY · PI Patsy M Nishina · 1998 to 2026
$12.4M
Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-ADU01AG061359 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, KASTENMULLER, GABI · 2018 to 2022
$10.0M
BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a TrialR01AG069930 · NIA · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F, VAN ELDIK, LINDA J · 2021 to 2025
$9.5M
GMP Production and Extended Toxicology of an Oral Formulation Drug for Alzheimer's DiseaseU01AG076480 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LINDA J VAN ELDIK, Daniel Martin Watterson · 2022 to 2026
$7.1M
NCATS NIH HHS U24 TR004440NCI NIH HHS P30 CA034196NEI NIH HHS R01 EY011996NEI NIH HHS R01 EY034988NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG031311NIA NIH HHS R01 AG066831NIA NIH HHS R01 AG069901NIA NIH HHS R01 AG069930NIA NIH HHS R21 AG083299NIA NIH HHS R42 AG062095NIA NIH HHS RF1 AG058942NIA NIH HHS RF1 AG059093NIA NIH HHS RF1 AG064859NIA NIH HHS RF1 AG075701NIA NIH HHS RF1 AG079125NIA NIH HHS T32 AG062409NIA NIH HHS U01 AG028561NIA NIH HHS U01 AG043415NIA NIH HHS U01 AG050636NIA NIH HHS U01 AG061359NIA NIH HHS U01 AG076480NIA NIH HHS U19 AG063744NIA NIH HHS U19 AG074866NIA NIH HHS U54 AG054345NIA NIH HHS U54 AG065187NIDA NIH HHS U01 DA051235NIH HHS S10 OD026880NIH HHS S10 OD030463NINDS NIH HHS R01 NS047586NINDS NIH HHS R01 NS056051
6 · The paper itself

Abstract

introductionIn September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field.

methodsDuring the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic.

resultsThe team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification of disease targets, (2) enhance factors promoting resilience, (3) de-risk clinical pipeline, and (4) centralize data management. DISCUSSION: In this report, we review these four objectives and propose innovations to expedite ADRD therapeutic pipelines.

Identifiers

PMID38469553
PMCPMC10925728
OpenAlexW4392665115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.