Evidence map›Paper›PMID 38469499›Full record

ArticleFrontiers in insect science2023

RNAi-mediated knockdown of two orphan G protein-coupled receptors reduces fecundity in the yellow fever mosquito

Nia I Keyes-Scott, Kyle R Swade, Lena R Allen, Kevin J Vogel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in insect science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nia I Keyes-ScottDepartment of Entomology, The University of Georgia, Athens, GA, United States.
Kyle R SwadeDepartment of Entomology, The University of Georgia, Athens, GA, United States.
Lena R AllenDepartment of Entomology, The University of Georgia, Athens, GA, United States.
Kevin J VogelDepartment of Entomology, The University of Georgia, Athens, GA, United States.
University of Georgia · US

Funding

Characterization of peptide hormone receptors in mosquito ovaries and their role in mosquito reproductionK22AI127849 · NIAID · UNIVERSITY OF GEORGIA · PI VOGEL, KEVIN JAMES · 2017 to 2018
$266k
NIAID NIH HHS K22 AI127849
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) control numerous physiological processes in insects, including reproduction. While many GPCRs have known ligands, orphan GPCRs do not have identified ligands in which they bind. Advances in genomic sequencing and phylogenetics provide the ability to compare orphan receptor protein sequences to sequences of characterized GPCRs, and thus gain a better understanding of the potential functions of orphan GPCRs. Our study sought to investigate the functions of two orphan GPCRs, AAEL003647 and AAEL019988, in the yellow fever mosquito,

Indexed as

GPCRinsect endocrinologyinsect physiologyreproductionvector biology

Identifiers

PMID38469499
PMCPMC10926455
OpenAlexW4386091293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.