Evidence map›Paper›PMID 38469353›Full record

ArticleFrontiers in cellular neuroscience2024

Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes.

Kyle A Lyman, Ye Han, Andrew P Robinson, Samuel E Weinberg, Daniel W Fisher, Robert J Heuermann, Reagan E Lyman, Dong Kyu Kim, Andreas Ludwig, Navdeep S Chandel and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Kyle A Lyman *Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.
Ye Han *Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Andrew P RobinsonDepartment of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University, Chicago, IL, United States.
Samuel E WeinbergDepartment of Medicine, Northwestern University, Chicago, IL, United States.
Daniel W FisherDepartment of Psychiatry, University of Washington, Seattle, WA, United States.
Robert J HeuermannDepartment of Neurology, Washington University, St. Louis, MO, United States.
Reagan E LymanHeritage College of Osteopathic Medicine, Ohio University, Dublin, OH, United States.
Dong Kyu KimDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States.
Andreas LudwigInstitut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany.
Navdeep S ChandelDepartment of Medicine, Northwestern University, Chicago, IL, United States.
Mark D DoesDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States.
Stephen D MillerDepartment of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University, Chicago, IL, United States.
Dane M ChetkovichDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Northwestern University · USVanderbilt University · USVanderbilt University Medical Center · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMassachusetts General Hospital · USOhio University · USUniversity of Washington · USWashington University in St. Louis · US

Funding

Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
HCN Channel Trafficking in EpilepsyR01NS059934 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHETKOVICH, DANE M · 2008 to 2017
$3.1M
Discovery of novel small molecule antidepressantsR01MH106511 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHETKOVICH, DANE M, SCHILTZ, GARY E · 2016 to 2018
$1.1M
Characterizing antidepressant-like effects of a novel peptide HCN channel inhibitorR21MH113262 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHETKOVICH, DANE M · 2017 to 2018
$430k
Evaluation of antidepressant-like effects of hippocampal HCN channel modulationR21MH104471 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHETKOVICH, DANE M · 2014 to 2015
$410k
NIA NIH HHS T32 AG052354NIMH NIH HHS R01 MH106511NIMH NIH HHS R21 MH104471NIMH NIH HHS R21 MH113262NINDS NIH HHS R01 NS059934
6 · The paper itself

Abstract

Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their respective current (I

Indexed as

EAEHCNIhmitochondriamultiple sclerosisoligodendrocyteoligodendrocyte progenitor cellTRIP8b

Identifiers

PMID38469353
PMCPMC10925711
OpenAlexW4392165471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.