Evidence map›Paper›PMID 38468916›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2024

Long-Term Efficacy of Successful Excisional Goniotomy with the Kahook Dual Blade.

Isabella V Wagner, Nithya Boopathiraj, Connor Lentz, Emily Aashna Dorairaj, Christian Draper, Devesh Kumar, Leticia Checo, Darby D Miller, Chelsey Krambeer, Syril Dorairaj

Open access · goldAbstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Ab Interno Goniotomy/Goniectomy TechniquesTurkish journal of ophthalmology · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Isabella V WagnerDepartment of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0001-5386-3692
Nithya BoopathirajDepartment of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.
Connor LentzDepartment of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.
Emily Aashna DorairajDepartment of Medicine, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.ORCID 0009-0008-7171-1308
Christian DraperDepartment of Ophthalmology, Eye Consultants, Spokane, WA, USA.
Devesh KumarDepartment of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, USA.
Leticia ChecoDepartment of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0003-0683-9598
Darby D MillerDepartment of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.
Chelsey KrambeerDepartment of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.
Syril DorairajDepartment of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.
WinnMed · USFlorida Atlantic University · USMedical College of Wisconsin · USMinnesota Eye Consultants · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To report clinical outcomes of successful excisional goniotomy with the Kahook Dual Blade (KDB), through 60 months. Patients and methods: This was a noncomparative, single-surgeon, retrospective review of eyes receiving successful KDB goniotomy with or without concomitant phacoemulsification between October 2015 and January 2016 with five years of uninterrupted follow-up. Intraocular pressure (IOP), number of glaucoma medications, best corrected visual acuity (BCVA), and complications were recorded. Primary outcomes included changes from baseline in IOP, medication use, and BCVA, through five years. Results: Fifty-two eyes of 28 patients were analyzed. Most eyes had mild primary open angle glaucoma (73%). Of the eyes analyzed, 41 underwent combined surgery and 11 underwent standalone surgery. With all eyes combined, mean (standard deviation) baseline IOP was 21.0 (4.1) mmHg and mean baseline medication use was 1.8 (1.1) medications per eye. Across time points at months 6, 12, 24, 36, 48, and 60, mean postoperative IOP ranged from 13.0 to 13.7 mmHg, representing mean reductions of 7.3-8.0 mmHg (34.7-38.3%; p <0.0001 at every time point). Similarly, mean medication use ranged from 0.4 to 0.6 medications per eye, representing mean reductions of 1.2-1.4 medications (66-75.5%; p <0.0001 at every time point). Mean logMAR BCVA improved from 0.321 (0.177) preoperatively to 0.015 (0.035) at month 60 (p < 0.0001). Conclusion: In eyes not requiring secondary surgical procedures (eg, long-term surgical successes), excisional goniotomy provided clinically and statistically significant reductions in both IOP and the need for medications that were highly consistent through five years of follow-up. KDB goniotomy appears to be highly successful in Caucasian patients with open angle glaucoma on ≥1 IOP-lowering medications at baseline and with no history of prior ocular surgery. Successful excisional goniotomy with the KDB can be expected to improve long-term glaucoma-related visual outcomes through IOP reduction and to improve quality of life through medication reduction.

Indexed as

glaucomagoniotomyintraocular pressureIOP-lowering medicationsminimally invasive glaucoma surgeryphacoemulsification

Identifiers

PMID38468916
PMCPMC10926857
OpenAlexW4392555561

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.