Evidence map›Paper›PMID 38468819›Full record

ArticleJournal of clinical tuberculosis and other mycobacterial diseases2024

A teenage girl with altered mental status and paraparesis.

Ryo Miyakawa, Janice Louie, Chris Keh, Lisa Chen, Babak Javid, Joel D Ernst, Neela Goswami, Felicia C Chow

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ryo MiyakawaDepartment of Pediatrics, University of California, San Francisco, USA.
Janice LouieDepartment of Medicine, University of California, San Francisco, USA.
Chris KehDepartment of Medicine, University of California, San Francisco, USA.
Lisa ChenDepartment of Medicine, University of California, San Francisco, USA.
Babak JavidDepartment of Medicine, University of California, San Francisco, USA.
Joel D ErnstDepartment of Medicine, University of California, San Francisco, USA.
Neela GoswamiCenters for Disease Control and Prevention, USA.
Felicia C ChowDepartment of Medicine, University of California, San Francisco, USA.
University of California, San Francisco · USCalifornia Department of Public Health · USCenters for Disease Control and Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A teenage girl presented with fever and altered mental status. MRI showed diffuse leptomeningeal enhancement of the brain and spine. She was diagnosed by a positive cerebrospinal fluid (CSF) culture with tuberculous (TB) meningitis and was started on anti-TB medications and corticosteroids. Her mental status improved, but she was noted to have proximal weakness of the lower extremities. In the course of tapering corticosteroids at week 11 of anti-TB therapy, she became acutely confused and febrile. MRI demonstrated interval development of tuberculomas in the brain and a mass lesion in the thoracic spine causing cord compression. Given the clinical picture was suggestive of a paradoxical reaction, the dose of corticosteroids was increased. Infliximab was added when repeat MRI revealed enlargement of the mass lesion in the spine with worsening cord compression. She was successfully tapered off of corticosteroids. Over several months, the patient's motor function recovered fully, and she returned to ambulating without assistance.

Indexed as

Host-directed therapyMeningitisParadoxical reactionTuberculosisTumor necrosis factor-alpha inhibitor

Identifiers

PMID38468819
PMCPMC10926304
OpenAlexW4392365445

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.