Evidence map›Paper›PMID 38468520›Full record

ArticleInfectious disorders drug targets2024

Antimalarial Effects of Nano Chloroquine Loaded Curcumin In vivo.

Taher Elmi, Fatemeh Tabatabaie, Mehdi Shafiee Ardestani, Abdolhossein Dalimi, Fatemeh Ghaffarifar, Zahra Zamani, Fatemeh Maleki

Abstract read
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In one paragraph

Article in Infectious disorders drug targets, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microbiology spectrum · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taher ElmiDepartment of Laboratory Science, School of Medicine, Islamic Azad University, Babol Branch, Babol, Iran.
Fatemeh TabatabaieDepartment of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mehdi Shafiee ArdestaniDepartment of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Abdolhossein DalimiDepartment of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Fatemeh GhaffarifarDepartment of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Zahra ZamaniBiochemistry Department, Pasteur Institute of Iran, Pasteur Avenue, Tehran. Iran.
Fatemeh MalekiDepartment of Parasitology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.

Funding

Iran University of Medical Sciences 96-04-30-32279
6 · The paper itself

Abstract

backgroundMalaria is still the deadliest parasitic disease caused by Plasmodium spp. Due to drug resistance and their unpleasant side effects, of conventional researchers are enormously seeking to achieve antimalarial drugs with more curative effective, less toxic and cost-affordable drugs using more advanced technology such as nanodrugs. PURPOSE: The present study aimed to examine the antimalarial effects of a novel synthesized nonochloroquine-loaded curcumin relying on dendrimer G2 in susceptible mice.

methodsAntimalarial activity and toxicity of the nanocomposite were examined on BALB/C mice with microscopy, checking RBCs morphology and related enzymatic activity rate.

resultsThe maximum inhibitory effect of the nanocomposite was seen at 10 mg/kg, killing 98% of

conclusionThe study showed that nonochloroquine-loaded curcumin had a promising inhibitory effect on

Indexed as

AntimalarialsChloroquineCurcuminMalariaMice, Inbred BALB CPlasmodium bergheiAnimalsDendrimersErythrocytesMiceNanocompositesAntimalarialsChloroquineCurcuminDendrimersantimalarial drugsBALB/CcurcuminNano chloroquinenanocompositeP. bergheiRBCs morphology.

Identifiers

PMID38468520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.