Evidence map›Paper›PMID 38468454›Full record

ArticleBrain and behavior2024

A retrospective, naturalistic study of deep brain stimulation and vagal nerve stimulation in young patients.

Deniz Yuruk, Can Ozger, Juan F Garzon, Paul A Nakonezny, Jennifer L Vande Voort, Paul E Croarkin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Deniz YurukResearch Fellow in the Department of Psychiatry and Psychology, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Can OzgerDepartment of Psychiatry and Psychology, Mayo Clinic Children's Research Center, and Mayo Clinic Depression Center, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-5669-9418
Juan F GarzonResearch Fellow in the Department of Psychiatry and Psychology, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.ORCID 0000-0003-2333-0195
Paul A NakoneznyDepartment Of Population And Data Sciences, UT Southwestern Medical Center, Dallas, Texas, USA.
Jennifer L Vande VoortDepartment of Psychiatry and Psychology, Mayo Clinic Children's Research Center, and Mayo Clinic Depression Center, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3630-4773
Paul E CroarkinDepartment of Psychiatry and Psychology, Mayo Clinic Children's Research Center, and Mayo Clinic Depression Center, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6843-6503
Mayo Clinic · USSouthwestern Medical Center · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent DepressionR01MH113700 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2017 to 2021
$2.5M
A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents with Suicidal Ideation Associated with Major Depressive DisorderR01MH124655 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2020 to 2023
$2.4M
NCATS NIH HHS UL1 TR000135NIMH NIH HHS R01 MH113700NIMH NIH HHS R01 MH124655
6 · The paper itself

Abstract

introductionInvasive neuromodulation interventions such as deep brain stimulation (DBS) and vagal nerve stimulation (VNS) are important treatments for movement disorders and epilepsy, but literature focused on young patients treated with DBS and VNS is limited. This retrospective study aimed to examine naturalistic outcomes of VNS and DBS treatment of epilepsy and dystonia in children, adolescents, and young adults.

methodsWe retrospectively assessed patient demographic and outcome data that were obtained from electronic health records. Two researchers used the Clinical Global Impression scale to retrospectively rate the severity of neurologic and psychiatric symptoms before and after patients underwent surgery to implant DBS electrodes or a VNS device. Descriptive and inferential statistics were used to examine clinical effects.

resultsData from 73 patients were evaluated. Neurologic symptoms improved for patients treated with DBS and VNS (p < .001). Patients treated with DBS did not have a change in psychiatric symptoms, whereas psychiatric symptoms worsened for patients treated with VNS (p = .008). The frequency of postoperative complications did not differ between VNS and DBS groups.

conclusionYoung patients may have distinct vulnerabilities for increased psychiatric symptoms during treatment with invasive neuromodulation. Child and adolescent psychiatrists should consider a more proactive approach and greater engagement with DBS and VNS teams that treat younger patients.

Indexed as

Deep Brain StimulationDrug Resistant EpilepsyDystoniaEpilepsyVagus Nerve StimulationAdolescentChildHumansRetrospective StudiesTreatment OutcomeYoung Adultadolescent psychologyneuropsychiatricsneurosurgerypsychiatry

Identifiers

PMID38468454
PMCPMC10928335
OpenAlexW4392711399

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.