Evidence map›Paper›PMID 38468443›Full record

ArticleCancer science2024

RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells.

Linxiang Gong, Dominic Chih-Cheng Voon, Joji Nakayama, Chiaki Takahashi, Susumu Kohno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Linxiang GongDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Dominic Chih-Cheng VoonInstitute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan.ORCID https://orcid.org/0000-0002-2963-9305
Joji NakayamaDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Chiaki TakahashiDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.ORCID https://orcid.org/0000-0003-3390-9563
Susumu KohnoDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.ORCID https://orcid.org/0000-0002-1448-9527

Funding

Daiichi-Sankyo TaNeDS (C1010568)Japan Agency for Medical Research and Development 19cm0106164h0001Japan Science and Technology Corporation Next Generation World-Leading Researchers (LS049)Japan Society for the Promotion of Science 17H03576Japan Society for the Promotion of Science 17K14992Japan Society for the Promotion of Science 17K19586Japan Society for the Promotion of Science 19K22555Japan Society for the Promotion of Science 20K07612Japan Society for the Promotion of Science 22K07209Japan Society for the Promotion of Science 23KJ1033
6 · The paper itself

Abstract

While loss of function (LOF) of retinoblastoma 1 (RB1) tumor suppressor is known to drive initiation of small-cell lung cancer and retinoblastoma, RB1 mutation is rarely observed in breast cancers at their initiation. In this study, we investigated the impact on untransformed mammary epithelial cells given by RB1 LOF. Depletion of RB1 in anon-tumorigenic MCF10A cells induced reversible growth arrest (quiescence) featured by downregulation of multiple cyclins and MYC, upregulation of p27

Indexed as

Down-RegulationEpithelial Cellsras ProteinsRetinoblastoma Binding ProteinsSignal TransductionBreast NeoplasmsCell Line, TumorCyclin-Dependent Kinase Inhibitor p27Epithelial-Mesenchymal TransitionFemaleHumansMammary Glands, HumanRetinoblastoma ProteinUbiquitin-Protein LigasesCyclin-Dependent Kinase Inhibitor p27ras ProteinsRetinoblastoma Binding ProteinsRetinoblastoma ProteinUbiquitin-Protein LigasesMYCquiescenceRASRB1RBL2/p130

Identifiers

PMID38468443
PMCPMC11093197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.