Trial reportPsychiatry and clinical neurosciences2024
Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J-SUPPORT 2001 Study).
Trial report in Psychiatry and clinical neurosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Smartphone cognitive behavioral therapy for prevention of depressive symptoms in patients with recurrent pregnancy loss: an exploratory decentralized, parallel-group, multicenter, open, individually randomized, fully factorial trial.Psychiatry and clinical neurosciences · 2026Trial
- Online peer support for breast cancer survivors: protocol for a decentralized multicenter open-label pilot randomized controlled trial (HOPE-BC study).International journal of clinical oncology · 2026Article
- Usability, feasibility, and acceptability of a smartphone-supported behavioral activation intervention for patients with advanced cancer.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2026Article
- Experiences of psychosomatic symptoms and self-management strategies among patients with advanced lung cancer undergoing chemotherapy: a qualitative study based on symptom management theory.Frontiers in public health · 2026Article
- Telepalliative Care on Quality of Life, Symptom Management, and Patient Satisfaction: A Systematic Review.Journal of multidisciplinary healthcare · 2026Review
- Trial characteristics, methods and reported challenges of decentralised clinical trials: a scoping review.BMJ open · 2025Article
- Assessment of digital therapeutics in decentralized clinical trials: A scoping review.PLOS digital health · 2025Article
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Authors and funding
31 authors.
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Abstract
aimPatients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone psychotherapy component to address depressive symptom.
methodsThis was a decentralized, parallel-group, multicenter, open, individually randomized, fully factorial trial. Patients aged ≥20 years with cancer were randomized by the presence/absence of three cognitive-behavioral therapy (CBT) skills (behavioral activation [BA], assertiveness training [AT], and problem-solving [PS]) on a smartphone app. All participants received psychoeducation (PE). The primary outcome was change in the patient health questionnaire-9 (PHQ-9) total score between baseline and week 8. Secondary outcomes included anxiety.
resultsIn total, 359 participants were randomized. Primary outcome data at week 8 were obtained for 355 participants (99%). The week 8 PHQ-9 total score was significantly reduced from baseline for all participants by -1.41 points (95% confidence interval [CI] -1.89, -0.92), but between-group differences in change scores were not significant (BA: -0.04, 95% CI -0.75, 0.67; AT: -0.16, 95% CI -0.87, 0.55; PS: -0.19, 95% CI -0.90, 0.52).
conclusionAs the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence-based recommendations regarding the use of specific smartphone psychotherapy.
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