ArticleJournal of clinical periodontology2025
Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia.
Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Number of Teeth and Posterior Occlusal Pairs by Sociodemographic Factors in the Finnish Adult Population, Results From the Healthy Finland 2023 Study.Journal of oral rehabilitation · 2026Article
- [Age-Related Changes in Occlusion and the Clinical Management and Prevention Strategies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Reduced Posterior Occlusal Contacts Are Associated With an Increased Risk of Stroke: A Retrospective Study Based on a Japanese Claims Database.Journal of the American Heart Association · 2026Article
- Association between masticatory function and cognitive ability in mild cognitive impairment.BMC geriatrics · 2026Article
- Association between dental implants and health outcomes in Korean patients with dementia: a retrospective cohort study.BMC oral health · 2026Article
- Advances in research on dental occlusion and brain function: neuroimaging correlates and molecular mechanisms.Frontiers in neurology · 2026Review
- A novel full digital workflow for dental autotransplantation: surgical accuracy and clinical outcomes in a prospective cohort study.Frontiers in oral health · 2026Article
- Impact of dental implant restoration on biomechanical stress distribution in the temporomandibular joint among patients with posterior tooth loss.Bioinformation · 2026Article
- Oral-Sarcopenia nexus in health disparities: chewing and blood mediated pathways in a Chinese aging cohort.BMC oral health · 2025Observational
- Clinical and Radiological Markers of Periodontal Status and Risk of Cognitive Decline and Incident Dementia.Journal of clinical periodontology · 2025Article
- The Effect of Dental Implant Restoration on the Biomechanics of the Temporomandibular Joint in Patients with Posterior Tooth Loss: A Pilot Study.Bioengineering (Basel, Switzerland) · 2025Article
- The association between cognitive impairment and oral health or oral hygiene behaviors among multiethnic older adults in Western China: a cross-sectional multicenter study.BMC public health · 2025Article
- Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia.Journal of clinical periodontology · 2025Article
- Loss of dental pulp potentially increased the risk of Alzheimer's dementia.Journal of dental sciences · 2025Article
- Prevalence of middle mesial canal in mandibular molars: A cross-sectional cone-beam computed tomography study.Journal of clinical and experimental dentistry · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimEmerging evidence suggests association of tooth loss with impaired cognition. However, the differential effects of anterior versus posterior tooth loss, occlusal support loss and chewing ability are not considered comprehensively. MATERIALS AND
methodsWe conducted cross-sectional (N = 4036) and longitudinal analyses (N = 2787) on data from Health 2000 and 2011 Surveys for associations of posterior occlusal support loss, anterior versus posterior tooth loss, and chewing ability with baseline cognition and 11-year cognitive decline. Additionally, 15-year incident dementia risk was investigated (N = 4073).
resultsAfter considering relevant confounders and potential reverse causality bias, posterior occlusal support loss significantly increased dementia risk across all categories indicative of posterior occlusal support loss (hazard ratios [HRs] between 1.99 and 2.89). Bilateral inadequate posterior occlusal support was associated with 11-year decline in overall cognition (odds ratio [OR] = 1.48:1.00-2.19), and unilateral inadequate posterior occlusal support with total immediate (OR = 1.62:1.14-2.30) and delayed recall decline (OR = 1.45:1.03-2.05). Moreover, posterior tooth loss was associated with dementia (HR = 2.23:1.27-3.91) and chewing ability with total immediate decline (OR = 1.80:1.04-3.13).
conclusionsPosterior tooth and occlusal support loss significantly increases dementia risk. The impact of posterior occlusal support loss appears to be dose-dependent, and this effect is distinct from that of dentures. Dental healthcare services should be particularly attentive to the state of posterior dentition. Further studies exploring possible mechanisms are warranted.
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