Evidence map›Paper›PMID 38468251›Full record

ArticleBMC oral health2024

Hard tissue formation in pulpotomized primary teeth in dogs with nanomaterials MCM-48 and MCM-48/hydroxyapatite: an in vivo animal study.

Sahar Talebi, Nosrat Nourbakhsh, Ardeshir Talebi, Amir Abbas Nourbakhsh, Abbas Haghighat, Maziar Manshayi, Hamid Reza Bakhsheshi, Razieh Karimi, Rahman Nazeri, Kenneth J D Mackenzie

Open access · goldAbstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sahar TalebiDentist, Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. sahar.talebi.dds@gmail.com.
Nosrat NourbakhshDepartment of Pediatric Dentistry, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Ardeshir TalebiDepartment of Pathology, Medical School, Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. talebi@med.mui.ac.ir.
Amir Abbas NourbakhshDepartment of Materials Science, Shahreza Branch, Islamic Azad University, Shahreza, Iran.
Abbas HaghighatDepartment of Maxillofacial Surgery, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Maziar ManshayiDVM. Dental Science Research Center. Dentistry faculty, Isfahan University of Medical Sciences, Isfahan, Iran.
Hamid Reza BakhsheshiAdvanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Razieh KarimiAdvanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Rahman NazeriDentist, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Kenneth J D MackenzieMacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, Wellington, New Zealand.
Isfahan University of Medical Sciences · IRIslamic Azad University of Najafabad · IRIslamic Azad University of Shahreza · IRMacDiarmid Institute for Advanced Materials and Nanotechnology · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis animal study sought to evaluate two novel nanomaterials for pulpotomy of primary teeth and assess the short-term pulpal response and hard tissue formation in dogs. The results were compared with mineral trioxide aggregate (MTA).

methodsThis in vivo animal study on dogs evaluated 48 primary premolar teeth of 4 mongrel female dogs the age of 6-8 weeks, randomly divided into four groups (n = 12). The teeth underwent complete pulpotomy under general anesthesia. The pulp tissue was capped with MCM-48, MCM-48/Hydroxyapatite (HA), MTA (positive control), and gutta-percha (negative control), and the teeth were restored with intermediate restorative material (IRM) paste and amalgam. After 4-6 weeks, the teeth were extracted and histologically analyzed to assess the pulpal response to the pulpotomy agent.

resultsThe data were analyzed using the Kruskal‒Wallis, Fisher's exact, Spearman's, and Mann‒Whitney tests. The four groups were not significantly different regarding the severity of inflammation (P = 0.53), extent of inflammation (P = 0.72), necrosis (P = 0.361), severity of edema (P = 0.52), extent of edema (P = 0.06), or connective tissue formation (P = 0.064). A significant correlation was noted between the severity and extent of inflammation (r = 0.954, P < 0.001). The four groups were significantly different regarding the frequency of bone formation (P = 0.012), extent of connective tissue formation (P = 0.047), severity of congestion (P = 0.02), and extent of congestion (P = 0.01). No bone formation was noted in the gutta-percha group. The type of newly formed bone was not significantly different among the three experimental groups (P = 0.320).

conclusionMCM-48 and MCM-48/HA are bioactive nanomaterials that may serve as alternatives for pulpotomy of primary teeth due to their ability to induce hard tissue formation. The MCM-48 and MCM-48/HA mesoporous silica nanomaterials have the potential to induce osteogenesis and tertiary (reparative) dentin formation.

Indexed as

Dental Pulp CappingDentin, SecondaryAnimalsBicuspidDental PulpDogsDrug CombinationsEdemaFemaleGutta-PerchaHydroxyapatitesInflammationOxidesTooth, DeciduousDrug CombinationsGutta-PerchaHydroxyapatitesOxidesAnimal studyDental materialDental pulpDental pulp therapyHard tissue formationHydroxyapatiteMCM-48NanoNanomaterialPrimary teeth, mineral trioxide aggregatePulpotomyPuppiesRegenerationTooth preservationVital pulpotomy

Identifiers

PMID38468251
PMCPMC10926592
OpenAlexW4392645744

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.