ArticleBMC public health2024
Association between higher triglyceride glucose index and increased risk of osteoarthritis: data from NHANES 2015-2020.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The association between dyslipidemia and hand osteoarthritis: a systematic review and meta-analysis.Clinical rheumatology · 2025Pooled it
- Does diabetes modify the triglyceride-glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants.Cardiovascular diabetology · 2025Pooled it
- Article
- Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review).International journal of molecular medicine · 2026Review
- Article
- Association of the combined atherosclerosis index of plasma and frailty index with arthritis in middle-aged and older adults: a cohort study.Scientific reports · 2026Article
- Predictive significance of triglyceride-glucose index in forecasting adverse cardiovascular events among Type 2 diabetes mellitus patients with co-existing metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies.Cardiovascular diabetology · 2026Article
- Refining Osteoarthritis Risk Prediction: Average Sagittal Abdominal Diameter Complements and Enhances Body Mass Index With Sex-Specific Insights From National Health and Nutrition Examination Survey.Health care science · 2026Article
- The association between life's crucial 9 and osteoarthritis in US adults: the mediating role of central adiposity.Nutrition & metabolism · 2026Article
- Association of Triglyceride-to-HDL Cholesterol Ratio with Osteoarthritis: Multicenter Evidence and Application of an Interactive Risk Visualization Tool.Journal of inflammation research · 2026Article
- Associations Between Metabolic Syndrome Index, Systemic Inflammatory Index, and Arthritis Subtype in the U.S. and Chinese Adults: A Mediation Analysis.Mediators of inflammation · 2026Article
- Triglyceride-glucose related indices, cardiometabolic multimorbidity, and risk of incident osteoarthritis: A prospective cohort study in UK Biobank.Therapeutic advances in musculoskeletal disease · 2026Article
- Association of estimated glucose disposal rate with erectile dysfunction: mediating role of neutrophil-to-lymphocyte ratio.Food & nutrition research · 2026Article
- Association between triglyceride glucose index and deep vein thrombosis following total knee arthroplasty: a retrospective case-control study.BMC geriatrics · 2025Article
- Elevated triglyceride-glucose index and risk of thymoma-associated myasthenia gravis: a prospective analysis from the UK Biobank.Cardiovascular diabetology · 2025Article
- Association between Osteoarthritis and the Triglyceride-Glucose Index in the Korean Population: A Large-Scale Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Multi-omics integration at cell type resolution uncovers gene-metabolite mechanisms underlying osteoarthritis heterogeneity.bioRxiv : the preprint server for biology · 2025Article
- Association of eight anthropometric indexes related to obesity with the prevalence of clinical osteoarthritis among American adults: a national cross-sectional study.European journal of medical research · 2025Article
- Association between the dietary inflammatory index and allergic rhinitis results from the National health and nutrition examination survey (2005-2006).Journal of health, population, and nutrition · 2025Article
- The predictive significance of the triglyceride-glucose index in forecasting adverse cardiovascular events among type 2 diabetes mellitus patients with co-existing hyperuricemia: a retrospective cohort study.Cardiovascular diabetology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe relationship between the triglyceride glucose (TyG) index and osteoarthritis (OA) remains unclear. The objective of this study was to examine potential associations between an elevated TyG index and an increased risk of OA prevalence.
methods3,921 participants with OA from the National Health and Nutrition Examination Survey (2015-2020) were included in this study. Participants were categorized into quartiles based on TyG index, which was determined using the formula: Ln [triglyceride (mg/dL) fasting blood glucose (mg/dL)/2]. Weighted multivariable regression, subgroup analyses, and threshold effect analyses were performed to calculate the independent association between TyG index and OA.
resultsA total of 25,514 people were enrolled, with a mean TyG index of 8.48 ± 0.65. The results of multivariable logistic regression analysis after full adjustment showed a significant association between higher TyG index values and an increased risk of OA. Specifically, each incremental unit increase in the TyG index was associated with a 634% higher risk of OA [OR = 7.34; 95% CI: 2.25, 23.93; p = 0.0010]. Based on interaction tests, age, gender, BMI, and smoking status did not significantly affect the relationship between the TyG index and OA, while diabetes showed a stronger positive correlation between the TyG index and OA.
conclusionAn increased risk of OA was associated with a higher TyG index. TyG could be a valuable predictor of OA and offer novel perspectives on the assessment and treatment of OA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.