Evidence map›Paper›PMID 38468114›Full record

ArticleCardiovascular engineering and technology2024

Establishment of a Biaxial Testing System for Characterization of Right Ventricle Viscoelasticity Under Physiological Loadings.

Kellan Roth, Wenqiang Liu, Kristen LeBar, Matt Ahern, Zhijie Wang

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Article in Cardiovascular engineering and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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3 · Its place in the literature

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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Kellan RothDepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Wenqiang LiuSchool of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
Kristen LeBarDepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Matt AhernDepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Zhijie WangDepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA. Zhijie.Wang@colostate.edu.ORCID 0000-0001-9551-516X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrior studies have indicated an impact of cardiac muscle viscoelasticity on systolic and diastolic functions. However, the studies of ventricular free wall viscoelasticity, particularly for that of right ventricles (RV), are limited. Moreover, investigations on ventricular passive viscoelasticity have been restricted to large animals and there is a lack of data on rodent species. To fill this knowledge gap, this study aims to develop a biaxial tester that induces high-speed physiological deformations to characterize the passive viscoelasticity of rat RVs.

methodsThe biaxial testing system was fabricated so that planar deformation of rat ventricle tissues at physiological strain rates was possible. The testing system was validated using isotropic polydimethylsiloxane (PDMS) sheets. Next, viscoelastic measurements were performed in healthy rat RV free walls by equibiaxial cyclic sinusoidal loadings and stress relaxation.

resultsThe biaxial tester's consistency, accuracy, and stability was confirmed from the PDMS samples measurements. Moreover, significant viscoelastic alterations of the RV were found between sub-physiological (0.1 Hz) and physiological frequencies (1-8 Hz). From hysteresis loop analysis, we found as the frequency increased, the elasticity and viscosity were increased in both directions. Interestingly, the ratio of storage energy to dissipated energy (W

conclusionThis work provides a new experimental tool to quantify the passive, biaxial viscoelasticity of ventricle free walls in both small and large animals. The dynamic mechanical tests showed frequency-dependent elastic and viscous behaviors of healthy rat RVs. But the ratio of dissipated energy to stored energy was maintained between frequencies. These findings offer novel baseline information on the passive viscoelasticity of healthy RVs in adult rats.

Indexed as

DimethylpolysiloxanesElasticityHeart VentriclesVentricular Function, RightAnimalsBiomechanical PhenomenaEquipment DesignMaleRatsRats, Sprague-DawleyReproducibility of ResultsStress, MechanicalViscositybaysilonDimethylpolysiloxanesDissipated energyHysteresisRelaxation modulusSiliconeStorage energy

Identifiers

PMID38468114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.