ArticleAdvances in neurobiology2024
Fractal Dimension Studies of the Brain Shape in Aging and Neurodegenerative Diseases.
Article in Advances in neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- Fractal Anatomy of Human Organs: A Narrative Review of Structure, Function, and Clinical Perspectives.Clinical anatomy (New York, N.Y.) · 2026Review
- Correlations Between Morpho-structural Properties of the Brain and Cognitive and Motor Deficits in Individuals with Traumatic Brain Injury.Neurotrauma reports · 2025Article
- Empirical Evidence for Extended Cognitive Systems.Cognitive science · 2021Article
- 3D structural complexity analysis of cerebellum in Chiari malformation type I.Medical & biological engineering & computing · 2017Article
- Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters.Human brain mapping · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
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Abstract
The fractal dimension is a morphometric measure that has been used to investigate the changes of brain shape complexity in aging and neurodegenerative diseases. This chapter reviews fractal dimension studies in aging and neurodegenerative disorders in the literature. Research has shown that the fractal dimension of the left cerebral hemisphere increases until adolescence and then decreases with aging, while the fractal dimension of the right hemisphere continues to increase until adulthood. Studies in neurodegenerative diseases demonstrated a decline in the fractal dimension of the gray matter and white matter in Alzheimer's disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia. In multiple sclerosis, the white matter fractal dimension decreases, but conversely, the fractal dimension of the gray matter increases at specific stages of disease. There is also a decline in the gray matter fractal dimension in frontotemporal dementia and multiple system atrophy of the cerebellar type and in the white matter fractal dimension in epilepsy and stroke. Region-specific changes in fractal dimension have also been found in Huntington's disease and Parkinson's disease. Associations were found between the fractal dimension and clinical scores, showing the potential of the fractal dimension as a marker to monitor brain shape changes in normal or pathological processes and predict cognitive or motor function.
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