Evidence map›Paper›PMID 38467925›Full record

ArticleProbiotics and antimicrobial proteins2025

Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway.

Jin-Ju Jeong, Yoo-Jeong Jin, Raja Ganesan, Hee Jin Park, Byeong Hyun Min, Min Kyo Jeong, Sang Jun Yoon, Mi Ran Choi, Satya Priya Sharma, You Jin Jang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jin-Ju Jeong *Institute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
Yoo-Jeong Jin *R&D Center, Chong Kun Dang Healthcare, Seoul, Republic of Korea.
Raja Ganesan *Institute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
Hee Jin ParkInstitute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
Byeong Hyun MinInstitute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
Min Kyo JeongInstitute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
Sang Jun YoonInstitute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
Mi Ran ChoiInstitute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
Satya Priya SharmaInstitute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.
You Jin JangR&D Center, Chong Kun Dang Healthcare, Seoul, Republic of Korea.
Uigi MinR&D Center, Chong Kun Dang Healthcare, Seoul, Republic of Korea.
Jong-Hyun LimR&D Center, Chong Kun Dang Healthcare, Seoul, Republic of Korea.
Kyeong Min NaDepartment of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute of Agricultural and Life Sciences, Seoul National University, Seoul, Korea.
Jieun ChoiDepartment of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute of Agricultural and Life Sciences, Seoul National University, Seoul, Korea.
Sang Hak HanDepartment of Pathology, College of Medicine, Hallym University, Chuncheon, Republic of Korea.
Young Lim HamDepartment of Nursing, Daewon University College Jecheon, Jecheon, Republic of Korea.
Do Yup Lee *Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute of Agricultural and Life Sciences, Seoul National University, Seoul, Korea. rome73@snu.ac.kr.
Byung-Yong Kim *R&D Center, Chong Kun Dang Healthcare, Seoul, Republic of Korea. bykim@ckdhc.com.
Ki Tae Suk *Institute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea. ktsuk@hallym.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diarrhea, a common gastrointestinal symptom in health problems, is highly associated with gut dysbiosis. The purpose of this study is to demonstrate the effect of multistrain probiotics (Sensi-Biome) on diarrhea from the perspective of the microbiome-neuron axis. Sensi-Biome (Lactiplantibacillus plantarum, Bifidobacterium animalis subsp. lactis, Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacterium bifidum, and Lactococcus lactis) was administered in a 4% acetic acid-induced diarrhea rat model at concentrations of 1 × 10

Indexed as

DiarrheaGastrointestinal MicrobiomeProbioticsSerotoninAnimalsFecesMaleRatsRats, Sprague-DawleySerotoninAcetic acidCytokinesDiarrheaMetabolitesMicrobiomeMultistrain probiotics

Identifiers

PMID38467925
PMCPMC12532644

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.