ArticleNature neuroscience2024
Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish.eLife · 2026Article
- Heart rate control by listening to light.Nature communications · 2026Article
- Article
- Active pixel power control for crosstalk-free all-optical neural interrogation.Nature communications · 2026Article
- Bridging Model and Experiment in Systems Neuroscience with Cleo: The Closed-Loop, Electrophysiology, and Optophysiology Simulation Testbed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain-computer interfaces as a causal probe for scientific inquiry.Trends in cognitive sciences · 2026Review
- Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces.Neurophotonics · 2026Review
- Identifying the factors governing internal state switches during nonstationary sensory decision-making.Nature communications · 2025Article
- A software platform for real-time and adaptive neuroscience experiments.Nature communications · 2025Article
- Silicon nitride PIC beam formers for light sheet fluorescent microscopy.Biomedical optics express · 2025Article
- A real-time all-optical interface for dynamic perturbation of neural activity during behavior.Cell reports methods · 2025Article
- Optimized in vivo two-photon imaging reveals the essential role of the contralateral eye in functional optic nerve regeneration in zebrafish larvae.Eye and vision (London, England) · 2025Article
- Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed.bioRxiv : the preprint server for biology · 2025Article
- Designed optogenetic tool for bridging single-neuronal multimodal information in intact animals.Nature communications · 2025Article
- Predicting neuronal firing from calcium imaging using a control theoretic approach.PLoS computational biology · 2025Article
- A sensitive soma-localized red fluorescent calcium indicator for in vivo imaging of neuronal populations at single-cell resolution.PLoS biology · 2025Article
- Article
- Optogenetic Brain-Computer Interfaces.Bioengineering (Basel, Switzerland) · 2024Review
- Closing the Experiment-Modeling-Perturbation Loop in Whole-Brain Neuroscience.Neuroscience bulletin · 2024Article
- Multifunctional Nanomaterials for Advancing Neural Interfaces: Recording, Stimulation, and Beyond.Accounts of chemical research · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Large-scale imaging of neuronal activities is crucial for understanding brain functions. However, it is challenging to analyze large-scale imaging data in real time, preventing closed-loop investigation of neural circuitry. Here we develop a real-time analysis system with a field programmable gate array-graphics processing unit design for an up to 500-megabyte-per-second image stream. Adapted to whole-brain imaging of awake larval zebrafish, the system timely extracts activity from up to 100,000 neurons and enables closed-loop perturbations of neural dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.