Evidence map›Paper›PMID 38467887›Full record

ArticleBiochemical genetics2025

BPIFB1, Serving as a Downstream Effector of EBV-miR-BART4, Blocks Immune Escape of Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression.

Jiaodi Cai, Li Xiao, Jiao Liu, Dan Wang, Yadong Zhou, Zhiming Liao, Guoqun Chen

Abstract read
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In one paragraph

Article in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiaodi CaiDepartment of Pathology, The Affiliated Changsha Hospital of Hunan Normal University (The Fourth Hospital of Changsha), No. 70, Lushan South Road, Yuelu District, Changsha, 410006, Hunan, People's Republic of China.
Li XiaoDepartment of Pathology, The Affiliated Changsha Hospital of Hunan Normal University (The Fourth Hospital of Changsha), No. 70, Lushan South Road, Yuelu District, Changsha, 410006, Hunan, People's Republic of China.
Jiao LiuDepartment of Pathology, The Affiliated Changsha Hospital of Hunan Normal University (The Fourth Hospital of Changsha), No. 70, Lushan South Road, Yuelu District, Changsha, 410006, Hunan, People's Republic of China.
Dan WangCancer Research Institute, Central South University, Changsha, 410006, Hunan, People's Republic of China.
Yadong ZhouDepartment of Pathology, The Affiliated Changsha Hospital of Hunan Normal University (The Fourth Hospital of Changsha), No. 70, Lushan South Road, Yuelu District, Changsha, 410006, Hunan, People's Republic of China.
Zhiming LiaoDepartment of Pathology, The Affiliated Changsha Hospital of Hunan Normal University (The Fourth Hospital of Changsha), No. 70, Lushan South Road, Yuelu District, Changsha, 410006, Hunan, People's Republic of China.
Guoqun ChenDepartment of Pathology, The Affiliated Changsha Hospital of Hunan Normal University (The Fourth Hospital of Changsha), No. 70, Lushan South Road, Yuelu District, Changsha, 410006, Hunan, People's Republic of China. gqcguoqunchen@163.com.

Funding

Project of Changsha Natural Science Foundation No.kq2202023
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common tumors of head and neck in the Southeast Asia. PD-L1-dependent immune escape plays a critical role involved in NPC development. BPIFB1 has previously reported to take tumor-suppressive actions on NPC cell proliferation and migration. Nonetheless, the function of BPIFB1 in immune escape remains largely elusive. Expression pattern on mRNA and protein levels of target genes in NPC patients' samples and cell lines were examined by qRT-PCR, western blot, and immunohistochemistry staining, respectively. The assessment of CD8

Indexed as

B7-H1 AntigenHerpesvirus 4, HumanMicroRNAsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsTumor EscapeApoptosisCD8-Positive T-LymphocytesCell Line, TumorEpstein-Barr Virus InfectionsGene Expression Regulation, NeoplasticHumansSTAT1 Transcription FactorB7-H1 AntigenCD274 protein, humanMicroRNAsSTAT1 protein, humanSTAT1 Transcription FactorBPIFB1EBV-miR-BART4Immune escapeNasopharyngeal carcinomaPD-L1

Identifiers

PMID38467887

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.