ArticleScientific reports2024
Comprehensive study reveals phenotypic heterogeneity in Klebsiella pneumoniae species complex isolates.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Genomic architecture of fourth-generation cephalosporin-resistant Klebsiella pneumoniae Species Complex (KpSC) from patients and their hospital environment in Uganda.BMC microbiology · 2026Article
- Revisiting definitions of hypervirulent and classical Klebsiella pneumoniae through virulence factors and disease phenotype.Communications medicine · 2026Article
- Genotypes, antibiotic resistance, and virulence diversity among Klebsiella pneumoniae species complex isolates in Taiwan.Gut pathogens · 2026Article
- Phenotypic and genome-based characterization ofFrontiers in microbiology · 2026Article
- Identification of robust species-specific marker genes for the demarcation of theJournal of medical microbiology · 2025Article
- KpSC-ID: a multiplex real-time PCR assay for the simultaneous detection of theMicrobiology (Reading, England) · 2025Article
- Molecular epidemiology and clinical features ofMicrobiology spectrum · 2025Article
- Complete genome sequences ofMicrobiology resource announcements · 2025Article
- The rapid detection of a neonatal unit outbreak of a wild-type Klebsiella variicola using decentralized Oxford Nanopore sequencing.Antimicrobial resistance and infection control · 2025Article
- Molecular Epidemiology and In-Depth Characterization ofInternational journal of molecular sciences · 2025Article
- Prevalence and molecular characteristics of colistin-resistant isolates among carbapenem-resistant Klebsiella pneumoniae in Central South China: a multicenter study.Annals of clinical microbiology and antimicrobials · 2025Article
- Multi-omics investigation reveals unique markers inFrontiers in microbiology · 2025Article
- Comprehensive Genome Analysis of a Human-Derived β-Lactam-ResistantInfection and drug resistance · 2025Article
- Genomic and Phenotypic Characterization of Extensively Drug-Resistant ClinicalInfection and drug resistance · 2025Article
- Article
- Genome sequence of a virulent and hypermucoviscous-like Klebsiella michiganensis clinical isolate.BMC research notes · 2023Article
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
Here, we conducted a comprehensive analysis of 356 Klebsiella pneumoniae species complex (KpSC) isolates that were classified as classical (cl), presumptive hypervirulent (p-hv) and hypermucoviscous-like (hmv-like). Overall, K. pneumoniae (82.3%), K. variicola (2.5%) and K. quasipneumoniae (2.5%) were identified. These isolates comprised 321 cl-KpSC, 7 p-hv-KpSC and 18 hmv-like-KpSC. A large proportion of cl-KpSC isolates were extended-spectrum-β-lactamases (ESBLs)-producers (64.4%) and 3.4% of isolates were colistin-resistant carrying carbapenemase and ESBL genes. All p-hv-KpSC showed an antibiotic susceptible phenotype and hmv-like isolates were found to be ESBL-producers (8/18). Assays for capsule production and capsule-dependent virulence phenotypes and whole-genome sequencing (WGS) were performed in a subset of isolates. Capsule amount differed in all p-hv strains and hmv-like produced higher capsule amounts than cl strains; these variations had important implications in phagocytosis and virulence. Murine sepsis model showed that most cl strains were nonlethal and the hmv-like caused 100% mortality with 3 × 10
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