ArticleTranslational psychiatry2024
Depression and cognition are associated with lipid dysregulation in both a multigenerational study of depression and the National Health and Nutrition Examination Survey.
Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Association between atherogenic index of plasma and depression risk: a meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Exploring the bidirectional relationship between depressive disorder and dyslipidemia: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Associations between immuno-metabolic markers, working memory, and functional brain activation in depressive and anxiety disorders.Brain, behavior, & immunity - health · 2026Article
- Associations Between Nutritional Status, Cognitive Performance, and Surrogate Metabolic Profiles in School-Aged Children.Nutrients · 2026Article
- Uncovering the metabolomic signatures in adolescent depression using a targeted metabolomics approach.BMC psychiatry · 2026Article
- Joint trajectories of sleep duration and depressive symptoms and risk of incident multimorbidity: a longitudinal analysis with machine learning prediction.BMC geriatrics · 2026Article
- High-density lipoprotein (HDL) in older patients with schizophrenia: implications for clinical and cognitive outcomes.BMC psychiatry · 2026Article
- Lipids and glucose fluctuations are associated with clinically diagnosed depression in older adults with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Prevalence and associated factors of psychotic symptoms in young first-episode, drug-naïve major depressive disorder patients with abnormal lipid metabolism.European journal of medical research · 2025Article
- Emotional stress: a prominent factor positively related to the onset and recurrence of bladder cancer as revealed by NHANES and a Chinese database.Annals of medicine · 2025Article
- The role of lipids in the effect of APOE2 on cognitive function: a causal mediation analysis.European journal of epidemiology · 2025Article
- Trace Amine-associated Receptors (TAARs): Candidate Targets in the Treatment of Bipolar Disorders.Actas espanolas de psiquiatria · 2025Review
- Immunometabolic Pathways: Investigating Mediators of Major Depressive Disorder and Atherosclerotic Cardiovascular Disease Comorbidity.Biological psychiatry global open science · 2025Article
- Metabolomics provides novel understanding of Melissa officinalis mechanism of action ensuring its calming effect on dogs.BMC veterinary research · 2025Article
- Differences in cognitive deficits and brain functional impairments between patients with first-episode and recurrent depression.BMC psychiatry · 2025Article
- Lipid metabolism, remodelling and intercellular transfer in the CNS.Nature reviews. Neuroscience · 2025Review
- Supplementation with Lentil (Foods (Basel, Switzerland) · 2025Article
- Article
- Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression.Comprehensive psychoneuroendocrinology · 2025Article
- Causal mediation analysis of the neuroprotection ofmedRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Chronic dysregulation of peripheral lipids has been found to be associated with depression and cognition, but their interaction has not been investigated. Growing evidence has highlighted the association between peripheral lipoprotein levels with depression and cognition with inconsistent results. We assessed the association between peripheral lipids, depression, and cognition while evaluating their potential interactions using robust clinically relevant predictors such as lipoprotein levels and chronic medical disorders that dysregulate lipoproteins. We report an association between peripheral lipids, depression, and cognition, suggesting a common underlying biological mechanism driven by lipid dysregulation in two independent studies. Analysis of a longitudinal study of a cohort at high or low familial risk for major depressive disorder (MDD) (n = 526) found metabolic diseases, including diabetes, hypertension, and other cardiovascular diseases, were associated with MDD and cognitive outcomes. Investigating a cross-sectional population survey of adults in the National Health and Nutrition Examination Survey 2011-2014 (NHANES) (n = 2377), depression was found to be associated with high density lipoprotein (HDL) and cognitive assessments. In the familial risk study, medical conditions were found to be associated with chronic lipid dysregulation and were significantly associated with MDD using the structural equation model. A positive association between chronic lipid dysregulation and cognitive scores was found in an exploratory analysis of the familial risk study. In a complementary study, analysis of NHANES revealed a positive association of HDL levels with cognition. Further analysis of the NHANES cohort indicated that depression status mediated the interaction between HDL levels and cognitive tests. Importantly, the protective effect of HDL on cognition was absent in those with depressive symptoms, which may ultimately result in worse outcomes leading to cognitive decline. These findings highlight the potential for the early predictive value of medical conditions with chronic lipid dyshomeostasis for the risk of depression and cognitive decline.
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