Evidence map›Paper›PMID 38467419›Full record

ArticleLife science alliance2024

Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity.

Macarena Pozo-Morales, Ansa E Cobham, Cielo Centola, Mary Cathleen McKinney, Peiduo Liu, Camille Perazzolo, Anne Lefort, Frédérick Libert, Hua Bai, Nicolas Rohner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Divergent 3D genome organization in livers of cave and surface morphs ofbioRxiv : the preprint server for biology · 2025
    Article
  7. Postprandial Sleep in Short-Sleeping Mexican Cavefish.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024
    Article
  8. Article
  9. Postprandial sleep in short-sleeping Mexican cavefish.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Macarena Pozo-MoralesIRIBHM, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0003-2654-1895
Ansa E CobhamStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0003-4688-2558
Cielo CentolaStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0009-0004-4099-991X
Mary Cathleen McKinneyStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0002-6819-1419
Peiduo LiuDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.ORCID 0009-0006-6270-5470
Camille PerazzoloIRIBHM, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Anne LefortIRIBHM, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Frédérick LibertIRIBHM, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Hua BaiDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, USA.ORCID 0000-0003-2221-7545
Nicolas RohnerStowers Institute for Medical Research, Kansas City, MO, USA nro@stowers.org.ORCID 0000-0003-3248-2772
Sumeet Pal SinghIRIBHM, Université Libre de Bruxelles (ULB), Brussels, Belgium sumeet.pal.singh@ulb.be.ORCID 0000-0002-5154-3318
Université Libre de Bruxelles · BEStowers Institute for Medical Research · USIowa State University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK, THOMAS KAUFMAN · 2014 to 2026
$13.5M
A genomic toolkit for functional interrogation of trait variation in an aquatic modelR24OD030214 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI KEENE, ALEX C, WARREN, WESLEY CHARLES · 2022 to 2025
$2.8M
Starvation resistance and resilience of metabolic dysfunction in cavefishDP2AG071466 · NIA · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI ROHNER, NICOLAS · 2020 to 2020
$2.5M
Autonomous and Non-Autonomous Regulation of Cardiac AgingR01AG058741 · NIA · IOWA STATE UNIVERSITY · PI BAI, HUA · 2019 to 2023
$1.5M
Role of peroxisome-mitochondrion communication in tissue agingR01AG075156 · NIA · IOWA STATE UNIVERSITY · PI Hua Bai · 2023 to 2026
$1.2M
NIA NIH HHS DP2 AG071466NIA NIH HHS R01 AG058741NIA NIH HHS R01 AG075156NIH HHS P40 OD018537NIH HHS R24 OD030214
6 · The paper itself

Abstract

Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic lipid accumulation (steatosis) during undernourishment can lead to lipotoxicity and atrophy of the liver. Here, we found that although surface populations of

Indexed as

Fatty LiverStarvationAnimalsAtrophyHumansLarvaZebrafish

Identifiers

PMID38467419
PMCPMC10927358
OpenAlexW4392650482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.