Evidence map›Paper›PMID 38466747›Full record

SynthesisPloS one2024

Health status of transgender people globally: A systematic review of research on disease burden and correlates.

Ayden I Scheim, Ashleigh J Rich, Dougie Zubizarreta, Mannat Malik, Kellan E Baker, Arjee J Restar, Leigh Ann van der Merwe, June Wang, Bianca Beebe, Kathleen Ridgeway and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Authentic Allyship for Trans and Gender Diverse People: A Patterns of Knowing Perspective in Nursing.Nursing philosophy : an international journal for healthcare professionals · 2026
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  7. Co-Development and Validation of a Patient-Reported Experience Measure for Trans and Gender Diverse Young People: A Multi-Stage Participatory Study Protocol.Health expectations : an international journal of public participation in health care and health policy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ayden I ScheimDepartment of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0001-8498-9829
Ashleigh J RichDepartment of Social Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America.
Dougie ZubizarretaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Mannat MalikDepartment of Health Behaviour, Gillings School of Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America.ORCID 0000-0002-9765-5710
Kellan E BakerWhitman-Walker Institute, Washington, District of Columbia, United States of America.
Arjee J RestarDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, United States of America.
Leigh Ann van der MerweSocial, Health and Empowerment Feminist Collective of Transgender Women of Africa (S.H.E.), East London, South Africa.
June WangJohns Hopkins University, Baltimore, Maryland, United States of America.
Bianca BeebeSchool of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.
Kathleen RidgewaySchool of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.
Stefan D BaralDepartment of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.
Tonia PoteatDepartment of Social Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of America.
Sari L ReisnerDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

Funding

LITE CONNECT: Addressing testing gaps and epidemiologic disparities of COVID-19 amongtransgender people in the United StatesUH3AI133669 · NIAID · JOHNS HOPKINS UNIVERSITY · PI REISNER, SARI, WIRTZ, ANDREA L · 2019 to 2022
$6.9M
Training Program for Scientists Conducting Research to Reduce HIV Health DisparitR25MH067127 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emily A Arnold, Torsten Brian Neilands · 2003 to 2026
$5.4M
Characterizing the role of social, behavioral, and economic stigmas as determinants of HIV and mental health across the USR01NR020437 · NINR · JOHNS HOPKINS UNIVERSITY · PI BARAL, STEFAN DAVID · 2021 to 2025
$3.9M
Leveraging Big Data Science to Focus the HIV Response in Countries with Generalized HIV EpidemicsR01AI170249 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BARAL, STEFAN DAVID · 2022 to 2025
$2.9M
Gendered Situated Vulnerabilities and Mental Health among Transgender Men in IndiaR21MH125263 · NIMH · DREXEL UNIVERSITY · PI SCHEIM, AYDEN I · 2021 to 2022
$423k
NIAID NIH HHS R01 AI170249NIAID NIH HHS UH3 AI133669NIMH NIH HHS R21 MH125263NIMH NIH HHS R25 MH067127NINR NIH HHS R01 NR020437
6 · The paper itself

Abstract

BACKGROUND AND

objectivesTransgender and gender diverse (trans) health research has grown rapidly, highlighting the need to characterize the scientific evidence base. We conducted a systematic review of peer-reviewed research on disease burden and correlates in trans adolescents and adults over a 20-month period to identify knowledge gaps and assess methodological characteristics including measurement of gender identity, community engagement, and study quality. DATA SOURCES, ELIGIBILITY CRITERIA, AND SYNTHESIS

methodsWe searched seven databases using terms related to (a) transgender populations and (b) health or disease. Eligible studies were in English, French, or Spanish and reported original quantitative data on mental health or substance use conditions, infectious diseases, or non-communicable conditions in at least 25 trans individuals aged 15+. Quality assessment was performed in duplicate on a 10% sample of articles and findings were summarized using narrative synthesis.

resultsThe 328 included studies were conducted in 45 countries, with most from North America (54%) and limited research from South Asia (3%), Sub-Saharan Africa (3%), and the Middle East and North Africa (2%). Most studies used cross-sectional designs (73%) and convenience sampling (65%). Only 30% of studies reported any form of community engagement. Mental health and substance use disorders were the most studied area (77% of studies) and non-communicable conditions the least (16%). Available data indicated that trans populations experience high disease burden with considerable heterogeneity within and across settings. Of 39 articles assessed for quality, 80% were rated as fair, 18% as poor, and 3% as good quality. CONCLUSIONS AND IMPLICATIONS: Geographic, gender-specific, and topical gaps remain in trans health, but we found more research from African countries, with transmasculine people, and on non-communicable conditions than previous syntheses. Areas for growth in trans health research include community engagement, non-binary health, chronic and age-related conditions, and health determinants. REGISTRATION: PROSPERO CRD42021234043.

Indexed as

Transgender PersonsAdolescentAdultCost of IllnessFemaleGlobal HealthHealth StatusHumansMaleMental Health

Identifiers

PMID38466747
PMCPMC10927095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.