Evidence map›Paper›PMID 38466519›Full record

ReviewPaediatric drugs2024

Treatment Options for Alopecia Areata in Children and Adolescents.

Linnea L Westerkam, Diana B McShane, Elizabeth L Nieman, Dean S Morrell

Abstract readReview
PubMed Publisher
In one paragraph

Review in Paediatric drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Linnea L WesterkamSchool of Medicine, University of North Carolina, Chapel Hill, NC, USA. linnea_westerkam@med.unc.edu.ORCID http://orcid.org/0000-0002-9815-9399
Diana B McShaneDepartment of Dermatology, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-3180-6528
Elizabeth L NiemanDepartment of Dermatology, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-9950-1053
Dean S MorrellDepartment of Dermatology, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6039-8215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alopecia areata (AA) lifetime incidence is around 2%, with many patients first experiencing symptoms during childhood. However, ritlecitinib is the only FDA-approved treatment for pediatric patients 12 years and older. This review outlines reported topical, injectable, and oral treatment options for pediatric patients with AA. Clinical studies were obtained via a PubMed search using the following search terms: alopecia areata, areata, universalis, or totalis and medication, therapy, treatment, drug, or management. Only studies with pediatric patients were included in this review. Commonly used therapies, including corticosteroids, methotrexate, and minoxidil, newer promising medications, such as Janus kinase inhibitors, and less frequently used topical and systemic treatments are included. A summary of the drug development pipeline and ongoing interventional clinical trials with pediatric patients is provided. Treatments demonstrate variable efficacy, and many patients require combination therapy for maximal response. More robust clinical data is needed for many of the medications reviewed in order to provide better care for these patients.

Indexed as

Alopecia AreataAdolescentAdrenal Cortex HormonesChildHumansJanus Kinase InhibitorsMinoxidilAdrenal Cortex HormonesJanus Kinase InhibitorsMinoxidil

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.