Evidence map›Paper›PMID 38466465›Full record

ArticleMolecular biology reports2024

Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease.

Shadi Setayeshi, Ali Hasanzadeh, Yousef Yahyapour, Ahad Alizadeh, Hossein Ghorbani, Fahimeh Nokhostin, Meghdad Bagheri, Farzin Sadeghi

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shadi SetayeshiStudent Research Committee, Babol University of Medical Sciences, Babol, Iran.
Ali HasanzadehDepartment of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Yousef YahyapourInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Ahad AlizadehHealth Products Safety Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Hossein GhorbaniDepartment of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Fahimeh NokhostinDepartment of Obstetrics and Gynecology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Meghdad BagheriDepartment of Microbiology and Biotechnology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Farzin SadeghiCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. sadeghi.farzin@yahoo.com.
Babol University of Medical Sciences · IRGolestan University · IRQazvin University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study examined the viral load and physical status of the human papillomavirus 16 (HPV-16) genome in non-cancerous, precancerous and cancerous cervical lesions.

methodsQuantitative real-time PCR was performed to determine HPV-16 E2 and E6 viral load in 132 cervical specimens. E2/E6 viral load ratio was used to determine the physical status of HPV-16 genome.

resultsE2 gene viral load was a significant (P < 0.001) predicting biomarker in differentiating non-cancerous from precancerous and cancerous samples. E6 gene viral load was significantly different between the groups (P < 0.001). The specificity and sensitivity of E2 and E6 in distinguishing SCC samples were 100% and 95% respectively.

conclusionHPV-16 viral load measured through E2 and E6 genes is a reliable indicator of lesion type.

Indexed as

Oncogene Proteins, ViralPapillomavirus InfectionsPrecancerous ConditionsUterine Cervical NeoplasmsDNA-Binding ProteinsDNA, ViralFemaleHuman papillomavirus 16HumansIranViral LoadDNA-Binding ProteinsDNA, ViralOncogene Proteins, ViralHigh grade squamous intraepithelial lesionHuman papillomavirus 16Low grade squamous intraepithelial lesionSquamous cell carcinoma

Identifiers

PMID38466465
OpenAlexW4392652487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.