Evidence map›Paper›PMID 38466424›Full record

ArticleMedical molecular morphology2024

Alpha-fetoprotein producing endometrioid carcinoma arising in an adenomyoma of the uterus.

Yuzo Oyama, Takahiro Kusaba, Kasumi Takao, Eri Obata, Mitsutake Yano, Kazuhiro Kawamura, Haruto Nishida, Tsutomu Daa

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In one paragraph

Article in Medical molecular morphology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuzo OyamaFaculty of Medicine, Department of Diagnostic Pathology, Oita University, 1-1, Idaigaoka, Hasama-Machi, Yufu, 879-5593, Japan.
Takahiro KusabaFaculty of Medicine, Department of Diagnostic Pathology, Oita University, 1-1, Idaigaoka, Hasama-Machi, Yufu, 879-5593, Japan.
Kasumi TakaoFaculty of Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu, Japan.
Eri ObataFaculty of Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu, Japan.
Mitsutake YanoFaculty of Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu, Japan.
Kazuhiro KawamuraFaculty of Medicine, Department of Diagnostic Pathology, Oita University, 1-1, Idaigaoka, Hasama-Machi, Yufu, 879-5593, Japan.
Haruto NishidaFaculty of Medicine, Department of Diagnostic Pathology, Oita University, 1-1, Idaigaoka, Hasama-Machi, Yufu, 879-5593, Japan. nharuto@oita-u.ac.jp.ORCID http://orcid.org/0000-0003-2959-8002
Tsutomu DaaFaculty of Medicine, Department of Diagnostic Pathology, Oita University, 1-1, Idaigaoka, Hasama-Machi, Yufu, 879-5593, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of alpha-fetoprotein-producing endometrioid carcinoma (AFP-EC) that originated within an adenomyoma of the uterine corpus. A 76-year-old Japanese woman was incidentally discovered to have a uterine tumor along with multiple lung nodules. Upon surgical removal of the uterus, it was revealed that the tumor was situated within the adenomyoma. The tumor exhibited microfollicular structures and solid growth patterns, with hyaline globules, clear cell glands, and primitive tumor cells. Immunohistochemical analysis indicated the presence of germ cell markers, including AFP, SALL4, and glypican3, leading to final diagnosis of AFP-EC. Histopathologically, AFP-ECs exhibit characteristics similar to those of AFP-producing neoplasms in other organs. Furthermore, a nomenclature issue arises when distinguishing AFP-ECs from yolk sac tumors of the endometrium in older patients due to their shared features. The concept of retrodifferentiation or neometaplasia suggests that "endometrioid carcinoma with yolk sac tumor differentiation" or "endometrioid carcinoma with a primitive phenotype" may serve as more fitting terms for the diverse spectrum of AFP-producing neoplasms in the endometrium. In conclusion, this case underscores the diagnostic challenges posed by AFP-ECs arising from adenomyomas and emphasizes the need for refining the nomenclature and classification of AFP-producing neoplasms within the endometrium.

Indexed as

Adenomyomaalpha-FetoproteinsCarcinoma, EndometrioidAgedBiomarkers, TumorEndometrial NeoplasmsFemaleGlypicansHumansImmunohistochemistryTranscription FactorsUterine Neoplasmsalpha-FetoproteinsBiomarkers, TumorGlypicansGPC3 protein, humanSALL4 protein, humanTranscription FactorsAdenomyomaAFP-ECAlpha-fetoproteinAlpha-fetoprotein-producing endometrioid carcinomaEndometriumYolk sac tumor differentiation

Identifiers

PMID38466424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.