Evidence map›Paper›PMID 38466423›Full record

ArticleSurgical endoscopy2024

Efficacy of endoscopic surveillance for pharyngeal mucosa during endoscopic resection for pharyngeal carcinoma: a multicenter prospective study.

Yuki Kimura, Yuichi Shimizu, Masanobu Taniguchi, Suguru Ito, Akira Dobashi, Kenichi Goda, Yusuke Nishimura, Keiko Yamamoto, Shin Ichihara, Akihito Watanabe

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuki KimuraDepartment of Otolaryngology Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Hokkaido, Japan.
Yuichi ShimizuDepartment of Gastroenterology, National Hospital Organization, Hokkaido Medical Center, 5-7, Yamanote, Nishi-ku, Sapporo, Hokkaido, 063-0005, Japan. yuichi0996@gmail.com.ORCID 0000-0001-5367-4832
Masanobu TaniguchiDepartment of Otolaryngology Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Hokkaido, Japan.
Suguru ItoDepartment of Otolaryngology Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Hokkaido, Japan.
Akira DobashiDepartment of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan.
Kenichi GodaDepartment of Gastroenterology, Dokkyo Medical University, Mibu, Tochigi, Japan.
Yusuke NishimuraDivision of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Keiko YamamotoDivision of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Shin IchiharaDepartment of Surgical Pathology, Sapporo Kosei General Hospital, Sapporo, Hokkaido, Japan.
Akihito WatanabeDepartment of Otolaryngology Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSince patients with pharyngeal squamous cell carcinoma (SCC) often have multiple pharyngeal lesions, evaluation of pharyngeal lesions before endoscopic resection (ER) is important. However, detailed endoscopic observation of the entire pharyngeal mucosa under conscious sedation is difficult. We examined the usefulness of endoscopic surveillance with narrow band imaging (NBI) and lugol staining for detection of pharyngeal sublesions during ER for pharyngeal SCC under general anesthesia (endoscopic surveillance during treatment; ESDT).

methodsFrom January 2021 through June 2022, we examined 78 patients who were diagnosed with superficial pharyngeal SCC and underwent ER. They underwent the ESDT and for patients who were diagnosed with new lesions of pharyngeal SCC or high-grade dysplasia (HGD) that were not detected in the endoscopic examination before treatment, ER were performed simultaneously for new lesions and the main lesions. The primary endpoint of this study was the detection rate of new lesions of pharyngeal SCC or HGD in the ESDT.

resultsFifteen of the 78 patients were diagnosed as having undetected new pharyngeal lesions in the ESDT and 10 (12.8%) (95% CI 6.9-22.2%) were histopathologically confirmed to have new lesions of pharyngeal SCC or HGD. Among the 13 lesions of SCC or HGD, 8 were found by NBI observation; however, 5 were undetectable using NBI but detectable by lugol staining. All of the 13 lesions had endoscopic findings of pink color sign on lugol staining.

conclusionsEndoscopic surveillance for pharyngeal sublesions during ER for pharyngeal SCC is feasible and useful.

Indexed as

Pharyngeal NeoplasmsAgedAged, 80 and overCarcinoma, Squamous CellEndoscopic Mucosal ResectionFemaleHumansIodidesMaleMiddle AgedMucous MembraneNarrow Band ImagingPharynxProspective StudiesIodidesLugol's solutionEndoscopic resectionEndoscopic surveillanceLugol stainingNarrow band imagingPharyngeal carcinoma

Identifiers

PMID38466423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.