Evidence map›Paper›PMID 38466410›Full record

ArticleArchives of gynecology and obstetrics2024

Pregnancy and neonatal outcomes in 25 pregnant women diagnosed with new-onset acute myeloid leukemia during pregnancy.

Jing Ding, YiHan Xiao, Jie Fu, Guoli Liu, Shanyamei Huang, Xiaodong Mo

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Article in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing DingDepartment of Pediatrics, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
YiHan XiaoDepartment of Pediatrics, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
Jie FuDepartment of Pediatrics, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
Guoli LiuDepartment of Gynecology and Obstetrics, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
Shanyamei HuangPeking University Institute of Hematology, Peking University People's Hospital, No.11, Xizhimen South Street, Beijing, 100044, People's Republic of China.
Xiaodong MoPeking University Institute of Hematology, Peking University People's Hospital, No.11, Xizhimen South Street, Beijing, 100044, People's Republic of China. mxd453@163.com.ORCID 0000-0002-9881-7945

Funding

Foundation of 2018 Beijing Key Clinical Specialty Construction Project-Pediatrics 2199000726
6 · The paper itself

Abstract

purposeThe aim was to analyze the pregnancy and neonatal outcomes of pregnant women with new- onset acute myeloid leukemia (AML) diagnosed during pregnancy.

methodsIn this retrospective study 25 pregnant women who were diagnosed with new-onset AML during pregnancy from January 2010 to January 2021 were enrolled.

resultsA total of 4, 13 and 8 pregnant women with new-onset AML were diagnosed during the first, second, and third trimesters, respectively. Twelve of the 25 pregnant women underwent therapeutic abortion and 13 gave birth (9 preterm and 4 full-term newborns). The gestational age at initial clinical manifestations (13.4 ± 3.7 vs. 27.7 ± 5.6 weeks, P < 0.01) and diagnosis (16.9 ± 4.4 vs. 29.7 ± 5.5 weeks, P < 0.01) was lower in the pregnant women who underwent therapeutic abortion than in those who gave birth. Eighty-four percent (21/25) of the pregnant women with new-onset AML during pregnancy survived and were in remission and all the newborns were born alive. Three of the 13 newborns were exposed to chemotherapy, but no congenital malformations were observed. Eight newborns were admitted to the neonatal intensive care unit (NICU), and all recovered. The complete blood counts and biochemical examinations of the 8 newborns were normal.

conclusionsNew-onset AML during an earlier stage of pregnancy may increase the risk of poor pregnancy outcomes. The neonatal outcomes of pregnant women with new-onset AML during pregnancy are good with proper treatment.

Indexed as

Leukemia, Myeloid, AcutePregnancy Complications, NeoplasticPregnancy OutcomeAbortion, TherapeuticAdultFemaleGestational AgeHumansInfant, NewbornPregnancyRetrospective StudiesYoung AdultAcute myeloid leukemiaNewbornOutcomesPregnancy

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.