Evidence map›Paper›PMID 38465942›Full record

ArticleACS nano2024

CTC-Race: Single-Cell Motility Assay of Circulating Tumor Cells from Metastatic Lung Cancer Patients.

Yang Liu, Wujun Zhao, Jamie Hodgson, Mary Egan, Christen N Cooper Pope, Glenda Hicks, Petros G Nikolinakos, Leidong Mao

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yang LiuSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-8747-4975
Wujun ZhaoFCS Technology, LLC, Athens, Georgia 30602, United States.
Jamie HodgsonUniversity Cancer and Blood Center, LLC, Athens, Georgia 30607, United States.
Mary EganUniversity Cancer and Blood Center, LLC, Athens, Georgia 30607, United States.
Christen N Cooper PopeUniversity Cancer and Blood Center, LLC, Athens, Georgia 30607, United States.
Glenda HicksUniversity Cancer and Blood Center, LLC, Athens, Georgia 30607, United States.
Petros G NikolinakosUniversity Cancer and Blood Center, LLC, Athens, Georgia 30607, United States.
Leidong MaoSchool of Electrical and Computer Engineering, College of Engineering, The University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-9473-5590
University Cancer and Blood Center · USUniversity of Georgia · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
HIGH RECOVERY RATE AND HIGH PURITY ENRICHMENT OF CIRCULATING TUMOR CELLSR41EB028191 · NIBIB · FCS TECHNOLOGY, LLC · PI ZHAO, WUJUN · 2019 to 2019
$225k
NCATS NIH HHS UL1 TR002378NIBIB NIH HHS R41 EB028191
6 · The paper itself

Abstract

Distinctive subpopulations of circulating tumor cells (CTCs) with increased motility are considered to possess enhanced tumor-initiating potential and contribute to metastasis. Single-cell analysis of the migratory CTCs may increase our understanding of the metastatic process, yet most studies are limited by technical challenges associated with the isolation and characterization of these cells due to their extreme scarcity and heterogeneity. We report a microfluidic method based on CTCs' chemotactic motility, termed as CTC-Race assay, that can analyze migrating CTCs from metastatic non-small-cell lung cancer (NSCLC) patients with advanced tumor stages and enable concurrent biophysical and biochemical characterization of them with single-cell resolution. Analyses of motile CTCs in the CTC-Race assay, in synergy with other single cell characterization techniques, could provide insights into cancer metastasis.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsNeoplastic Cells, CirculatingBiomarkers, TumorHumansBiomarkers, Tumorcancer metastasiscell migrationcell motilitycirculating tumor cellssingle-cell analysis

Identifiers

PMID38465942
PMCPMC10976960
OpenAlexW4392651387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.