Evidence map›Paper›PMID 38465861›Full record

ArticleCancer biology & therapy2024

Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression.

Yusi Wang, Hongyan Zou, Wei Ji, Min Huang, Benhui You, Nan Sun, Yuandong Qiao, Peng Liu, Lidan Xu, Xuelong Zhang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Yusi WangLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Hongyan ZouLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Wei JiLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Min HuangLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Benhui YouLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Nan SunLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Yuandong QiaoLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Peng LiuLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Lidan XuLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Xuelong ZhangLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Mengdi CaiLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Ye KuangDepartment of Gynecology and Obstetrics, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
Songbin FuLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Wenjing SunLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Xueyuan JiaLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Jie WuLaboratory of Medical Genetics, Harbin Medical University, Harbin, China.ORCID 0000-0003-1525-7864
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Double minutes (DMs), extrachromosomal gene fragments found within certain tumors, have been noted to carry onco- and drug resistance genes contributing to tumor pathogenesis and progression. After screening for SUMO-related molecule expression within various tumor sample and cell line databases, we found that SUMO-conjugating enzyme UBC9 has been associated with genome instability and tumor cell DM counts, which was confirmed both

Indexed as

Chromosome AberrationsDNA DamageCell NucleusHumansIn Situ Hybridization, FluorescenceUbiquitin-Conjugating Enzyme UBC9Ubiquitin-Conjugating Enzyme UBC9DNA damage repairdouble minutesgenome instabilitySUMOylationUBC9

Identifiers

PMID38465861
PMCPMC10936631
OpenAlexW4392645575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.