Evidence map›Paper›PMID 38465662›Full record

ArticleBJPsych open2024

Loneliness in adolescence and prescription of psychotropic drugs in adulthood: 23-year longitudinal population-based and registry study.

Rubén Rodríguez-Cano, Karianne Lotre, Tilmann von Soest, Eline Borger Rognli, Jørgen Gustav Bramness

Open access · goldAbstract read
In one paragraph

Article in BJPsych open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Rubén Rodríguez-CanoDepartment of Psychology, Norwegian University of Science and Technology (NTNU), Norway; and PROMENTA Research Center, Department of Psychology, University of Oslo, Norway.ORCID https://orcid.org/0000-0001-6934-2939
Karianne LotreInstitute for Clinical Medicine, UiT - The Arctic University of Norway, Norway.
Tilmann von SoestPROMENTA Research Center, Department of Psychology, University of Oslo, Norway; and Norwegian Social Research (NOVA), OsloMet - Oslo Metropolitan University, Norway.
Eline Borger RognliSection for Clinical Addiction Research, Division of Mental Health and Addiction, Oslo University Hospital, Norway.
Jørgen Gustav BramnessInstitute for Clinical Medicine, UiT - The Arctic University of Norway, Norway; Department of Alcohol, Tobacco and Drugs, Norwegian Institute of Public Health, Trondheim, Norway; and Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Hamar, Norway.
Centre for Arctic Gas Hydrate, Environment and Climate · NONorwegian Institute of Public Health · NOOsloMet – Oslo Metropolitan University · NOOslo University Hospital · NOUniversity of Oslo · NO

Funding

Norges Forskningsråd 288083Norges Forskningsråd 301010
6 · The paper itself

Abstract

backgroundThe role of adolescent loneliness in adult mental health and prescriptions of psychotropic drugs remains underexplored.

aimsWe aim to determine whether (a) experiencing loneliness in adolescence and (b) changes in loneliness from adolescence to adulthood are prospectively associated with prescriptions for a variety of psychotropic drugs in adulthood.

methodWe used data from a Norwegian population-based sample with 2602 participants, collected across four waves between 1992 and 2006. Loneliness was assessed at each wave, with survey data linked to medicinal drug prescription records from the Norwegian Prescription Database. We identified prescription histories of antipsychotics, mood stabilisers, antidepressants and benzodiazepines from 2007 to 2015, for each participant. We use latent growth curve analyses to model the relationship of adolescent loneliness and loneliness change from adolescence to adulthood, with subsequent psychotropic drugs prescription.

resultsAdolescents with heightened loneliness, and adolescents whose loneliness increased into young adulthood, had a greater likelihood of being prescribed antipsychotics, mood stabilisers and antidepressants in adulthood. These associations remained significant after adjustment for confounders such as sociodemographic characteristics, conduct problems, substance use and mental health problems.

conclusionsLoneliness in adolescence and its adverse development over a span of 15 years was linked to higher risk of receiving prescriptions for antipsychotics, mood stabilisers and antidepressants later in life. The findings may indicate that loneliness increases the risk for developing psychotic disorders, bipolar disorders and major depression.

Indexed as

bipolar disorderdrug prescriptionsLoneliness trajectoriesmental disorderspsychotic disorders

Identifiers

PMID38465662
PMCPMC10951847
OpenAlexW4392648990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.