Evidence map›Paper›PMID 38465478›Full record

ArticleEuropean journal of neurology2024

Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis.

Maria Janina Wendebourg, Matthias Weigel, Claudia Weidensteiner, Laura Sander, Eva Kesenheimer, Nicole Naumann, Tanja Haas, Philipp Madoerin, Nathalie Braun, Christoph Neuwirth and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maria Janina WendebourgDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0003-4812-8807
Matthias WeigelDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Claudia WeidensteinerDivision of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.
Laura SanderDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Eva KesenheimerDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Nicole NaumannDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Tanja HaasDivision of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.
Philipp MadoerinDivision of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.
Nathalie BraunNeuromuscular Diseases Unit/ALS Clinic, Kantonsspital Sankt Gallen, St. Gallen, Switzerland.
Christoph NeuwirthNeuromuscular Diseases Unit/ALS Clinic, Kantonsspital Sankt Gallen, St. Gallen, Switzerland.
Markus WeberNeuromuscular Diseases Unit/ALS Clinic, Kantonsspital Sankt Gallen, St. Gallen, Switzerland.
Kathleen JahnClinics of Respiratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Ludwig KapposDepartment of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Cristina GranzieraDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Kathi SchweikertDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Michael SinnreichDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Oliver BieriDivision of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.
Regina SchlaegerDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0003-2056-5765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIn amyotrophic lateral sclerosis (ALS), there is an unmet need for more precise patient characterization through quantitative, ideally operator-independent, assessments of disease extent and severity. Radially sampled averaged magnetization inversion recovery acquisitions (rAMIRA) magnetic resonance imaging enables gray matter (GM) and white matter (WM) area quantitation in the cervical and thoracic spinal cord (SC) with optimized contrast. We aimed to investigate rAMIRA-derived SC GM and SC WM areas and their association with clinical phenotype and disability in ALS.

methodsA total of 36 patients with ALS (mean [SD] age 61.7 [12.6] years, 14 women) and 36 healthy, age- and sex-matched controls (HCs; mean [SD] age 63.1 [12.1] years, 14 women) underwent two-dimensional axial rAMIRA imaging at the inter-vertebral disc levels C2/3-C5/C6 and the lumbar enlargement level T

resultsCompared to HCs, GM and WM areas were reduced in patients at all cervical levels (p < 0.0001). GM area (p = 0.0001), but not WM area, was reduced at T

conclusionPatients with ALS assessed by rAMIRA imaging show significant cervical and thoracic SC GM and SC WM atrophy. SC GM area correlates with muscle strength and clinical disability. GM area reduction at T

Indexed as

Amyotrophic Lateral SclerosisAtrophyGray MatterMagnetic Resonance ImagingAgedCervical CordCervical VertebraeFemaleHumansMaleMiddle AgedSpinal CordThoracic VertebraeWhite Matteramyotrophic lateral sclerosisimaging markersmagnetic resonance imagingmotor neuron diseasesspinal cord imaging

Identifiers

PMID38465478
PMCPMC11235652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.