Evidence map›Paper›PMID 38465008›Full record

ArticleThe Pan African medical journal2023

An in-vivo experimental evaluation of the efficacy of fish-derived antimicrobial peptides against multidrug-resistant

Agharid Ali Al-Rasheed, Bashiru Garba, Kareem Obayes Handool, Karim Alwan Al-Jashamy, Mohamed Naji Ahmed Odhah, Najib Isse Dirie, Hassan Mohd Daud

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In one paragraph

Article in The Pan African medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Agharid Ali Al-RasheedDepartment of Microbiology, Faculty of Veterinary Medicine, Tikrit University, Tikrit, Iraq.
Bashiru GarbaDepartment of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria.
Kareem Obayes HandoolDepartment of Veterinary Directorate, Ministry of Agriculture, Baghdad, Iraq.
Karim Alwan Al-JashamyDepartment of Radiology and Sonar Technology, Bilad Alrafidain University College, Baghdad, Iraq.
Mohamed Naji Ahmed OdhahDepartment of Veterinary Public Health, Faculty of Veterinary Medicine, Thamar University, Dhamar, Yemen.
Najib Isse DirieDepartment of Urology, Dr. Sumait Hospital, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, Somalia.
Hassan Mohd DaudDepartment of Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: due to the fact that antimicrobial peptides antimicrobial peptides (AMPs) from climbing perch have not been fully explored for their antimicrobial potency, this investigation was undertaken to explore that possibility. Methods: antimicrobial peptides (AMPs) from the mucous secretion of climbing perch were obtained and an in-vivo analysis was conducted using mice. Results: the results showed inhibitory effects on multidrug-resistant multidrug-resistant Pseudomonas aeruginosa with reduced mortality from 100% among the non-treated group to 25%. Similarly, the level of serum transaminase enzymes (AST and ALT), creatinine levels, and pro-inflammatory cytokines (TNF-α and IL-6) were all found to be higher in the non-treatment group compared to the AMP-treatment group. Also, extensive tissue damage in the lung, liver, and spleen of the non-treated control group mice was observed based on the histopathological lesions recorded. As expected, AMPs from climbing perch significantly alleviated multidrug-resistant P. aeruginosa infection in-vivo and produced enhanced therapeutic efficacy superior to the ciprofloxacin treatment. Conclusion: this study provides insight into the potential antimicrobial activity of fish innate immune system-derived peptides that could serve as a candidate for the substitute of antibiotics.

Indexed as

Anti-Infective AgentsPseudomonas InfectionsAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesDrug Resistance, Multiple, BacterialMiceMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntimicrobial peptidesantimicrobial resistancehistopathological analysisPseudomonas aeruginosaserum biochemistry

Identifiers

PMID38465008
PMCPMC10924623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.