ArticleWorld journal of psychiatry2024
Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression.
Article in World journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The nature and interpretation of BOLD signals in white matter - A review.Magnetic resonance imaging · 2026Review
- White matter functional connectome gradient dysfunction in major depressive disorder.Psychoradiology · 2025Article
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8 authors.
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Abstract
backgroundMajor depression disorder (MDD) constitutes a significant mental health concern. Epidemiological surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults, with a corresponding increased risk of suicide. In studying brain dysfunction associated with MDD in adole-scents, research on brain white matter (WM) is sparse. Some researchers even mistakenly regard the signals generated by the WM as noise points. In fact, studies have shown that WM exhibits similar blood oxygen level-dependent signal fluctuations. The alterations in WM signals and their relationship with disease severity in adolescents with MDD remain unclear.
aimTo explore potential abnormalities in WM functional signals in adolescents with MDD.
methodsThis study involved 48 adolescent patients with MDD and 31 healthy controls (HC). All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview (MINI) suicide inventory. In addition, a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects' image data. The DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations (fALFF) and regional homogeneity, followed by a two-sample
resultsCompared to HC, individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body, left posterior limb of the internal capsule, right superior corona radiata, and bilateral posterior corona radiata [
conclusionAdolescents with MDD involves changes in WM functional signals, and these differences in brain regions may increase the risk of suicide.
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