ArticleCell reports. Physical science2024
Atomic structures of naphthalene dipeptide micelles unravel mechanisms of assembly and gelation.
Article in Cell reports. Physical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 18 citations in OpenAlex.
- Co-assembly and self-sorting are not mutually exclusive in enantiomeric peptide systems.Chemical science · 2026Article
- Light-triggered modulation in donor-acceptor dipeptide assemblies.Chemical communications (Cambridge, England) · 2026Article
- Atomic-precision π-driven peptide hydrogel nanofibers with ordered water channels.Nature communications · 2026Article
- Lithium-selective supramolecular assembly and capture by tripeptide gelators.Chemical science · 2026Article
- Shear-Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Tutorial: Machine-Learning-Based CREASE-2D Analysis of 2D SAXS Profiles to Characterize Anisotropic Nanostructures in Soft Materials.ACS measurement science au · 2026Article
- Article
- Emerging self-assembled peptide hydrogels for enhanced wound healing.Nanomedicine (London, England) · 2025Review
- Cryo-EM for atomic characterization of supramolecular gels.Faraday discussions · 2025Article
- Fragment-Based Approach for Hierarchical Nanotube Assembly of Small Molecules in Aqueous Phase.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Propagation of Orientation Across Lengthscales in Sheared Self-Assembling Hierarchical Suspensions via Rheo-PLI-SAXS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Context-Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides.Journal of the American Chemical Society · 2025Article
- Cryo-EM reconstruction of helical polymers: Beyond the simple cases.Quarterly reviews of biophysics · 2024Review
- Metal Cross-Linked Supramolecular Gel Noodles: Structural Insights and Antibacterial Assessment.Biomacromolecules · 2024Article
- Reversibly Tuning the Viscosity of Peptide-Based Solutions Using Visible Light.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Helical reconstruction, again.Current opinion in structural biology · 2024Review
- Applications of microscopy and small angle scattering techniques for the characterisation of supramolecular gels.Beilstein journal of organic chemistry · 2024Review
- Forging out-of-equilibrium supramolecular gels.Nature synthesis · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Peptide-based biopolymers have gained increasing attention due to their versatile applications. A naphthalene dipeptide (2NapFF) can form chirality-dependent tubular micelles, leading to supramolecular gels. The precise molecular arrangement within these micelles and the mechanism governing gelation have remained enigmatic. We determined, at near-atomic resolution, cryoelectron microscopy structures of the 2NapFF micelles LL-tube and LD-tube, generated by the stereoisomers (l,l)-2NapFF and (l,d)-2NapFF, respectively. The structures reveal that the fundamental packing of dipeptides is driven by the systematic π-π stacking of aromatic rings and that same-charge repulsion between the carbonyl groups is responsible for the stiffness of both tubes. The structural analysis elucidates how a single residue's altered chirality gives rise to markedly distinct tubular structures and sheds light on the mechanisms underlying the pH-dependent gelation of LL- and LD-tubes. The understanding of dipeptide packing and gelation mechanisms provides insights for the rational design of 2NapFF derivatives, enabling the modulation of micellar dimensions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.